Managing Panic Disorder During Pregnancy: Seeking Help and Medication Adjustments - Psychiatry

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Pregnancy anxiety


Hello Doctor, I am currently 18 weeks pregnant.
Before pregnancy, I was taking medication for panic disorder, but I stopped for a while after becoming pregnant, which led to a severe relapse of my condition.
I have been experiencing panic and anxiety, even having some distressing thoughts.
After three months, my doctor prescribed 10 mg of Escitalopram (Lexapro), to be taken once daily in the morning, noon, and evening.
However, I have been feeling nauseous and still very tense and fearful.
Should I expect to adapt to this medication over time? How long might that take? My mood fluctuates daily, which severely disrupts my life.
Should I consider changing my medication? I feel that Escitalopram is not as effective as the previous medication I was taking.

Happy, 30~39 year old female. Ask Date: 2022/08/07

Dr. Lin Mianzhang reply Psychiatry


Hello, Happy: It usually takes 2 to 4 weeks for Ebilin to show significant effects.
If there is no noticeable improvement after 4 weeks, it is recommended to increase the dosage.
This medication does not have as pronounced effects as other antidepressants, but it has minimal impact on the fetus during pregnancy, classified as Category B.
(Note: Medications are categorized based on their safety for the fetus from safest to most dangerous as A, B, C, D, and X, with A and B being relatively safe, and X indicating significant risk.
Most antidepressants, including Ebilin, are classified as Category C, with a few in Category D, which still carry some risks.) Therefore, the physician's decision to change your medication is also for the safety of the fetus.
However, if the therapeutic effect is inadequate, it may be necessary to discuss with your doctor whether to adjust the dosage or switch medications, as maintaining your emotional stability and not affecting your daily life is also very important.
Wishing you safety and health!

Reply Date: 2022/08/07

More Info


Managing panic disorder during pregnancy can be particularly challenging, especially when considering the safety of medications for both the mother and the developing fetus. It’s important to approach this situation with caution and to work closely with healthcare providers to find the best treatment plan.

Firstly, it’s crucial to understand that pregnancy can significantly affect mental health. Hormonal changes, physical discomfort, and the emotional stress of impending motherhood can exacerbate anxiety and panic disorders. Your experience of increased panic and anxiety after stopping your medication is not uncommon. Many women find that their pre-existing mental health conditions can worsen during pregnancy, leading to a cycle of distress that can be difficult to manage.

Regarding the medication you mentioned, Iproniazid (often referred to as "怡必隆"), it is important to note that this medication is a monoamine oxidase inhibitor (MAOI) and is generally not the first-line treatment for panic disorder, especially during pregnancy. While it may have been prescribed to you, its safety profile during pregnancy is not as well-established as some other medications. The nausea you are experiencing could be a side effect of the medication, and it may take some time for your body to adjust. However, if the side effects are severe or if you feel that the medication is not effectively managing your symptoms, it is essential to communicate this with your healthcare provider.

Considerations for Medication During Pregnancy:
1. Risk vs. Benefit Analysis: Medications are classified into categories based on their safety during pregnancy. Category A is the safest, while Category D indicates evidence of risk to the fetus. It’s crucial to discuss the classification of any medication you are taking with your doctor.


2. Alternative Medications: If Iproniazid is not effective or causes intolerable side effects, your doctor may consider switching you to a different medication. Some SSRIs (Selective Serotonin Reuptake Inhibitors), such as sertraline or fluoxetine, are often considered safer options during pregnancy and may be more effective for panic disorder.

3. Non-Pharmacological Interventions: In addition to medication, therapy can be a valuable tool in managing panic disorder. Cognitive-behavioral therapy (CBT) has been shown to be effective for anxiety disorders and can help you develop coping strategies to manage panic attacks and anxiety symptoms without medication.

4. Support Systems: Building a strong support system is vital. Engaging with friends, family, or support groups can provide emotional support and reduce feelings of isolation. Additionally, consider discussing your feelings with a mental health professional who specializes in perinatal mental health.

5. Monitoring Symptoms: Keep a journal of your symptoms, noting when they occur and their severity. This information can be helpful for your healthcare provider in adjusting your treatment plan.

6. Emergency Plan: If you experience thoughts of self-harm or severe distress, it is crucial to seek immediate help. Do not hesitate to contact your healthcare provider or go to the emergency room if you feel overwhelmed.

In conclusion, managing panic disorder during pregnancy requires a careful balance of medication, therapy, and support. It is essential to maintain open communication with your healthcare providers about your symptoms, medication side effects, and any concerns you may have. They can help you navigate your treatment options to ensure both your well-being and that of your baby. Remember, you are not alone in this journey, and there are resources and support available to help you through this challenging time.

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