Struggling with Insomnia After Stopping Lorazepam: Seeking Guidance - Psychiatry

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I don't know how to use the medication?


I previously took Lorazepam for over three months, and stopping the medication has resulted in insomnia for over a year now (I stopped after three weeks, and I wonder if that was too quick).
My symptoms of autonomic nervous system dysregulation are limited to stomach pain, nausea, and a feeling of wanting to vomit.
Before taking Lorazepam, I never experienced insomnia; now, even with Dongjian (likely referring to a sleep aid), I can only sleep for 1-3 hours before waking up.
Although I can lie down and fall back asleep, I feel increasingly fatigued, and I have been struggling with low energy during the day for a year.
Recently, I consulted two clinics.
One prescribed Dongjian Quetiapine, half a tablet of Clonazepam (0.5 mg, a long-acting benzodiazepine), and a quarter of 30 mg of Lurasidone (all taken at bedtime).
The other clinic prescribed Lorazepam 2 mg, half a tablet, Alprazolam 0.25 mg, one tablet, and half a tablet of Zolpidem (all taken at bedtime).
One clinic prescribed long-acting medications, while the other prescribed short-acting ones, but I have the same symptoms.
I am unsure which approach is more suitable or which medications are less likely to lead to dependence and can be discontinued more easily.
Currently, due to poor sleep, I have taken a quarter of Clonazepam for the past few days, but it seems ineffective, providing the same sleep duration as without medication.
A half tablet allows me to sleep for 4-5 hours.
Should I continue taking it on the fourth day? I also wonder how long it will take to return to my previous state.
I have read online that discontinuation can lead to poor sleep in the latter half of the night, and it may persist for months or even years.
Seeing this makes me question how much longer I can endure this or if I should return to Lorazepam and taper off more slowly.
I hope the physician can provide me with answers, and I would be very grateful.

Xiao Xiao, 30~39 year old female. Ask Date: 2022/09/15

Dr. Lin Mianzhang reply Psychiatry


Hello, Xiao Xiao: It seems that you are experiencing symptoms of insomnia combined with autonomic nervous system dysfunction.
If you are concerned about the issue of addiction, I would recommend that taking an antidepressant may be a more fundamental solution.
As for sleeping pills, they should only be used as an adjunct, and whether to use long-acting or short-acting sleeping medications depends on your sleep patterns; there is no definitive answer as to which is better.
Since I have not personally evaluated you, I cannot provide specific recommendations regarding your diagnosis.
I suggest that you discuss medication adjustments with your psychiatrist during your outpatient visit.
Wishing you peace and good health.

Reply Date: 2022/09/15

More Info


Struggling with insomnia after stopping Lorazepam can be a challenging experience, and it's understandable to seek guidance during this difficult time. Based on your description, it seems that you have been dealing with insomnia for over a year after discontinuing Lorazepam, which you had taken for three months. The symptoms you are experiencing, such as waking up frequently during the night and feeling increasingly fatigued during the day, are common among individuals who have stopped using benzodiazepines (BZD) like Lorazepam.

When you stop taking benzodiazepines, especially after prolonged use, your body can go through withdrawal symptoms, which may include insomnia. This withdrawal can lead to a rebound effect, where the original symptoms that led to the use of the medication—such as anxiety or sleep disturbances—can return, sometimes even more intensely. The duration of these withdrawal symptoms can vary significantly among individuals. While some may find relief within weeks, others may experience prolonged symptoms lasting several months or even years.

You mentioned that you have been prescribed various medications by different doctors, including Quetiapine, Clonazepam, and Lorazepam again. Each of these medications has its own profile regarding efficacy, side effects, and potential for dependence. Quetiapine is an atypical antipsychotic that is sometimes used off-label for insomnia, while Clonazepam is another benzodiazepine that can help with sleep but carries a risk of dependence similar to Lorazepam. Lorazepam, as you know, is effective for short-term management of anxiety and insomnia but can lead to tolerance and dependence if used long-term.

It's crucial to have an open dialogue with your healthcare providers about your concerns regarding dependence and the effectiveness of the medications prescribed. Since you are experiencing minimal improvement with the current medications, it may be worth discussing alternative treatment options or a more gradual approach to medication management. Some patients find that a combination of pharmacological and non-pharmacological treatments can be beneficial.
Non-pharmacological treatments for insomnia include cognitive-behavioral therapy for insomnia (CBT-I), which has been shown to be effective in treating chronic insomnia. CBT-I focuses on changing the thoughts and behaviors that contribute to sleep difficulties. Additionally, practicing good sleep hygiene—such as maintaining a consistent sleep schedule, creating a comfortable sleep environment, and avoiding stimulants like caffeine—can also help improve sleep quality.

If you are considering returning to Lorazepam, it is essential to do so under the guidance of a healthcare professional. They can help you devise a tapering schedule that minimizes withdrawal symptoms while addressing your insomnia. It is generally recommended to taper off benzodiazepines slowly rather than stopping abruptly, as this can reduce the risk of withdrawal symptoms and rebound insomnia.

In summary, your journey through insomnia after stopping Lorazepam is complex and may require a multifaceted approach. Engage in discussions with your healthcare providers about your treatment options, including the potential benefits of non-benzodiazepine medications, CBT-I, and lifestyle modifications. Remember that recovery from insomnia can take time, and it's essential to be patient with yourself as you navigate this process.

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