Impact of Amoxicillin on Emergency Contraceptive Effectiveness - Obstetrics and Gynecology

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Interactions of Emergency Contraceptive Pills


I have recently been taking the contraceptive pill, Qlaira, for ten days.
For the past three days, I have been suffering from acute pharyngitis and have been taking amoxicillin, which was prescribed by my doctor, two hours before taking the contraceptive pill.
I have read online that amoxicillin may affect the efficacy of contraceptive pills.
I would like to ask how much longer I need to take the pill to ensure contraceptive effectiveness.

Niming, 10~19 year old female. Ask Date: 2022/09/19

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have an impact.
Wishing you good health.

Reply Date: 2022/09/19

More Info


When it comes to the interaction between Amoxicillin and emergency contraceptive pills (ECPs), it's important to clarify some common misconceptions. Amoxicillin is a type of penicillin antibiotic that is often prescribed to treat bacterial infections, such as acute pharyngitis. The concern regarding antibiotics and their potential to interfere with the effectiveness of hormonal contraceptives, including ECPs, has been a topic of discussion for many years.

First, it's crucial to note that the majority of antibiotics, including Amoxicillin, do not significantly affect the efficacy of hormonal contraceptives. The primary concern arises from the fact that some antibiotics can alter the gut flora or affect the metabolism of contraceptive hormones, which could theoretically reduce their effectiveness. However, extensive research has shown that Amoxicillin does not have a clinically significant impact on the effectiveness of hormonal contraceptives. This means that if you are taking Amoxicillin while on ECPs, you should not be overly concerned about a reduction in contraceptive effectiveness.

In your case, since you have been taking the emergency contraceptive pill (ECP) for ten days and have also been prescribed Amoxicillin for your throat infection, you can rest assured that the Amoxicillin is unlikely to interfere with the contraceptive effect of the ECP. The ECPs are designed to prevent ovulation, fertilization, or implantation, and their effectiveness is not significantly compromised by Amoxicillin.

However, it is essential to consider other factors that could influence the effectiveness of your contraceptive method. For instance, if you have experienced vomiting or diarrhea as a side effect of taking Amoxicillin, this could potentially affect the absorption of the ECP. In such cases, it may be advisable to consult your healthcare provider for further guidance.

As for how long you should continue taking the ECPs to ensure contraceptive effectiveness, it is generally recommended to follow the prescribed regimen as directed by your healthcare provider. If you have taken the ECP as directed and have not experienced any gastrointestinal issues that could affect absorption, you should be adequately protected against pregnancy.

In summary, Amoxicillin does not significantly impact the effectiveness of emergency contraceptive pills. You can continue taking your ECPs as prescribed without worrying about the interaction with Amoxicillin. If you have any further concerns or experience any unusual symptoms, it is always best to consult your healthcare provider for personalized advice and reassurance. Your health and peace of mind are paramount, so don't hesitate to reach out for professional guidance when needed.

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Dr. Cao Guotao reply Obstetrics and Gynecology
Hello, it generally does not have an impact, so there's no need to worry. Wishing you good health.

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