Struggling with Insomnia After Stopping Lorazepam: Seeking Guidance - Psychiatry

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I'm not sure how to use the medication?


I previously took Lorazepam for over three months, and stopping the medication has caused me insomnia for over a year now (I stopped after three weeks; I wonder if that was too quick).
My symptoms of autonomic nervous system dysregulation are limited to stomach pain, nausea, and a feeling of wanting to vomit.
Before taking Lorazepam, I never experienced insomnia.
Now, even with Dongjian, I can only sleep for 1-3 hours before waking up.
Although I can lie down and fall back asleep for a bit, I feel increasingly fatigued.
I’ve been struggling with this for a year.
Recently, I consulted two clinics.
One prescribed Dongjian Quetiapine, half a tablet of Clonazepam (0.5 mg, a long-acting benzodiazepine), and a quarter of 30 mg of Lurasidone (all taken at bedtime).
The other clinic prescribed Lorazepam 2 mg, half a tablet of Alprazolam (0.25 mg), and half a tablet of Trazodone (10 mg, all taken at bedtime).
One doctor prescribed long-acting medications, while the other prescribed short-acting ones, but I have the same symptoms.
I’m unsure which approach is more suitable or which medications are less likely to lead to dependence and can be discontinued more easily.
Currently, due to poor sleep, I took a quarter of Clonazepam for the past few days, but it hasn’t been effective; my sleep duration is the same as when I didn’t take any medication.
Half a tablet allows me to sleep for 4-5 hours.
Should I continue taking it on the fourth day? I also don’t know how long it will take to return to my previous state.
I’ve read some information online stating that stopping medication can lead to poor sleep in the latter half of the night, which may persist for months or even years.
Seeing this makes me wonder how much longer I can endure this or if I should return to Lorazepam and taper off slowly.
I hope the physician can provide me with answers; I would be very grateful.

Xiao Xiao, 30~39 year old female. Ask Date: 2022/09/21

Dr. Liang Sunyuan reply Psychiatry


Hello, Xiao Xiao: There are many causes of insomnia, some of which are related to anxiety and depression.
However, prolonged poor sleep can make it difficult for emotional and physical states to recover.
It is advisable to take the medications prescribed by your doctor with confidence, and if you have any concerns, you can always return to discuss them with your physician.
Wishing you a speedy recovery.

Reply Date: 2022/09/21

More Info


Struggling with insomnia after stopping Lorazepam can be a challenging experience, especially when the symptoms persist for an extended period. It's important to understand that the withdrawal from benzodiazepines like Lorazepam can lead to a range of symptoms, including insomnia, anxiety, and other physical symptoms. The duration and intensity of these withdrawal symptoms can vary significantly from person to person.

When you stopped taking Lorazepam after three months of use, it is possible that the abrupt cessation contributed to your ongoing insomnia. While some individuals may experience a relatively quick resolution of withdrawal symptoms, others may find that their insomnia persists for months or even years. This phenomenon is sometimes referred to as "protracted withdrawal syndrome," where symptoms can linger long after the drug has been discontinued.

Your current symptoms, such as waking up frequently during the night and feeling increasingly fatigued during the day, are not uncommon among those who have recently stopped benzodiazepines. The fact that you did not experience insomnia prior to taking Lorazepam suggests that your body may still be adjusting to the absence of the medication. Additionally, the gastrointestinal symptoms you mentioned, like nausea and stomach pain, may be related to your autonomic nervous system dysregulation, which can be exacerbated by stress and anxiety.

Regarding the medications you are currently prescribed, it is essential to have a discussion with your healthcare provider about the best approach for your situation. The medications you mentioned, such as Quetiapine, Clonazepam, and others, vary in their mechanisms of action and potential for dependence. Clonazepam is a long-acting benzodiazepine, while Quetiapine is an atypical antipsychotic that is sometimes used off-label for insomnia. Lorazepam, as you know, is also a benzodiazepine but has a shorter half-life compared to Clonazepam.

When considering which medication to use, it's crucial to weigh the benefits against the risks of dependence and side effects. Benzodiazepines can be effective for short-term management of insomnia, but they do carry a risk of tolerance and dependence, especially with prolonged use. Non-benzodiazepine alternatives, such as certain antidepressants or melatonin receptor agonists, may be worth exploring if you are concerned about the potential for addiction.

In addition to medication, non-pharmacological approaches to managing insomnia can be beneficial. Cognitive Behavioral Therapy for Insomnia (CBT-I) is a structured program that helps individuals identify and change thoughts and behaviors that contribute to sleep problems. Implementing good sleep hygiene practices—such as maintaining a consistent sleep schedule, creating a comfortable sleep environment, and avoiding caffeine and electronics before bedtime—can also help improve sleep quality.

Ultimately, the path to recovery from insomnia after stopping Lorazepam may take time, and it is essential to be patient with yourself. Regular follow-ups with your healthcare provider can help monitor your progress and make necessary adjustments to your treatment plan. If you find that your current medications are not providing relief, do not hesitate to discuss alternative options with your doctor.

In summary, while it can be disheartening to experience prolonged insomnia after stopping Lorazepam, there are various strategies and treatments available. Open communication with your healthcare provider, combined with a holistic approach that includes both medication and behavioral strategies, can help you navigate this challenging period and work towards restoring your sleep.

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