Exploring Serratiopeptidase for Cervical Radiculopathy Relief - Neurosurgery

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Cervical radiculopathy (starting from February)


Regarding the use of serratiopeptidase for cervical radiculopathy, it is important to consult with your physician before starting any new supplement or medication.
Serratiopeptidase is an enzyme that may have anti-inflammatory properties, which could potentially help with pain and inflammation associated with conditions like cervical radiculopathy.
However, clinical evidence supporting its effectiveness specifically for this condition is limited.
Your current symptoms, including the tingling and nerve impulses in your left shoulder, arm, and fingers when bending your head backward, along with difficulty sleeping, suggest ongoing nerve irritation or compression.
The medications you are currently taking, such as Lyrica (pregabalin) and vitamin B12, along with physical therapy involving cervical traction, are common approaches to managing these symptoms.
The MRI findings indicate multilevel disc bulges and protrusions, along with mild spinal canal stenosis and bilateral narrowing of the neural foramina, which can contribute to your radiculopathy.
It is crucial to address these underlying issues with your healthcare provider, who may consider additional treatments or adjustments to your current regimen based on your ongoing symptoms and response to therapy.

Mr. Xin, 50~59 year old female. Ask Date: 2022/09/28

Dr. Zhang Junwei reply Neurosurgery


Without a detailed clinical assessment, it is not possible to address medication-related questions.

Reply Date: 2022/09/28

More Info


Serratiopeptidase, also known as serrapeptase, is an enzyme derived from the silkworm that is often marketed as a dietary supplement for its purported anti-inflammatory and analgesic properties. It has been studied for various conditions, including pain and inflammation associated with musculoskeletal disorders. However, when it comes to cervical radiculopathy, the evidence supporting the efficacy of serratiopeptidase is limited and not robust.

Cervical radiculopathy occurs when a nerve root in the cervical spine becomes compressed or irritated, often due to conditions such as herniated discs, osteophyte formation, or degenerative disc disease. The symptoms can include pain, numbness, tingling, and weakness in the arms and hands, as you've described. Your MRI findings indicate multilevel disc bulges and osteophyte complexes, which can contribute to nerve root compression and the symptoms you are experiencing.

While serratiopeptidase may have some anti-inflammatory effects, it is essential to understand that it is not a first-line treatment for cervical radiculopathy. The primary treatment options typically include physical therapy, pain management with medications (such as gabapentinoids like Lyrica), and possibly corticosteroid injections to reduce inflammation and pain. In more severe cases, surgical intervention may be necessary to relieve nerve compression.

In your case, you are already on a regimen that includes Lyrica, which is effective for neuropathic pain, and you are receiving physical therapy, including traction. These approaches are generally more established and supported by clinical evidence for treating cervical radiculopathy. The addition of serratiopeptidase may not significantly alter your treatment outcomes, and its use should be discussed with your healthcare provider.

Moreover, the symptoms you are experiencing—such as the tingling and pain radiating down your arm—suggest that the nerve root is likely being affected by the structural changes in your cervical spine. While some patients report subjective improvement with serratiopeptidase, it is crucial to approach such supplements with caution, especially since they may interact with other medications or have side effects.

In summary, while serratiopeptidase may offer some benefits in terms of inflammation reduction, it should not replace conventional treatments for cervical radiculopathy. It is advisable to continue with your current treatment plan and consult your healthcare provider before adding any new supplements to ensure they are appropriate for your specific condition. Regular follow-ups and possibly further imaging studies may be necessary to monitor the progression of your cervical spine issues and adjust your treatment plan accordingly.

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