Muscle Fasciculations: Causes, Concerns, and When to Seek Help - Neurology

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Fasciculation


Hello Doctor, since my diagnosis over a week ago, I have been experiencing visible muscle twitching throughout my body.
I consulted a neurologist and underwent an electromyography (EMG), and the doctor informed me that everything was normal and no fasciculations were detected.
They suggested that I might be experiencing autonomic nervous system dysfunction and did not provide a follow-up appointment.
However, I feel that my muscle twitching has recently worsened! In the past couple of days, I experienced continuous twitching in the back of my thigh for two hours before sleep, and it continued until noon after I woke up.
I also feel some tightness in my arches and occasional soreness in my arms.
I would like to ask the doctor: (1) Is it possible for benign fasciculation syndrome to cause such prolonged twitching? (2) Could muscle twitching also be a symptom of long COVID? (3) What are the distinguishing features between the muscle twitching of amyotrophic lateral sclerosis (ALS) and benign fasciculation syndrome? (4) If I continue to experience muscle twitching in two to three months, should I return to the doctor for another EMG? (5) If the EMG did not capture any muscle twitching, does that make the diagnosis less accurate? Is it certain that an EMG for ALS will always detect abnormalities? Thank you, Doctor.
Your answers will be very helpful to me.
Wishing you peace and well-being.

Mr. Hong, 20~29 year old female. Ask Date: 2022/11/04

Dr. Jiang Junyi reply Neurology


Hello Mr.
Hong,
You mentioned that "for two consecutive days, I experienced jumping in the back of my thighs for two hours before sleep, and after getting up, it continued for a while until noon.
I also feel a bit of tightness in my arches, and my arms occasionally feel sore." You are concerned about amyotrophic lateral sclerosis (ALS): typically, it presents with lower motor neuron signs on the same side of the body (such as weakness, atrophy, and fasciculations) and upper motor neuron signs (such as increased tendon reflexes, Hoffmann's sign, Babinski's sign, or muscle spasms).
If an electromyography (EMG) is performed, it should reveal active denervation in more than three limbs, while nerve conduction studies should be normal, without evidence of conduction block.
"Fasciculations may also be a symptom of long COVID," and this symptom is quite common.
Muscle twitching while awake may warrant consideration of certain metabolic disorders, such as hyperthyroidism or electrolyte imbalances.
Additionally, some nerve-stimulating foods, such as caffeine, may exacerbate muscle twitching while awake.
Thank you for your inquiry.
If you have further questions, feel free to discuss them! Wishing you good health and peace.
Dr.
Jiang Junyi, Taoyuan Medical Center

Reply Date: 2022/11/04

More Info


Hello! Thank you for reaching out with your concerns about muscle fasciculations. I understand that experiencing muscle twitching can be quite distressing, especially when it seems to worsen over time. Let’s address your questions one by one, and I’ll provide some additional context to help you understand the situation better.

1. Can benign muscle fasciculations last for extended periods?
Yes, benign muscle fasciculations can indeed persist for extended periods. These involuntary muscle contractions are often harmless and can be triggered by various factors, including stress, fatigue, caffeine intake, or even dehydration. While they can be bothersome, benign fasciculations typically do not indicate a serious underlying condition. However, if they become more frequent or intense, it’s essential to monitor the situation closely.

2. Could muscle twitching be a symptom of long COVID?
Muscle fasciculations have been reported as a symptom in some individuals recovering from COVID-19, often referred to as "long COVID." This condition can manifest in various ways, including neurological symptoms like muscle twitching, fatigue, and cognitive difficulties. If you suspect that your symptoms may be related to a previous COVID-19 infection, it would be beneficial to discuss this with your healthcare provider, who can help you explore this possibility further.

3. How can one differentiate between fasciculations in ALS (Amyotrophic Lateral Sclerosis) and benign fasciculations?
The twitching associated with ALS is often accompanied by other symptoms, such as muscle weakness, atrophy, and changes in reflexes. In contrast, benign fasciculations typically do not lead to weakness or muscle wasting. If you are experiencing persistent muscle twitching without accompanying weakness or other neurological symptoms, it is more likely to be benign. However, if you have concerns about ALS, it is crucial to discuss them with your doctor, who can perform a thorough evaluation.

4. Should I return for another EMG if the fasciculations persist for two to three months?
If your muscle twitching continues for an extended period, it is reasonable to follow up with your healthcare provider. They may recommend another electromyography (EMG) test to assess muscle activity and rule out any underlying conditions. It’s essential to communicate any changes in your symptoms, as this information can help guide your doctor’s recommendations.

5. If an EMG does not capture fasciculations, does that affect the accuracy of the diagnosis?
An EMG is a valuable tool for assessing muscle and nerve function, but it is not infallible. In cases of benign fasciculations, the twitching may not always be captured during the test, especially if it is intermittent. Conversely, in conditions like ALS, abnormalities may be present on the EMG. However, a normal EMG does not entirely rule out the possibility of a neurological disorder; it simply means that no significant abnormalities were detected at that time.

In summary, while muscle fasciculations can be concerning, they are often benign and related to factors such as stress or fatigue. However, if you notice changes in your symptoms or if they persist, it is essential to consult with your healthcare provider for further evaluation. They can help determine the best course of action and whether additional testing is necessary. Remember, your health and peace of mind are paramount, so don’t hesitate to seek help when needed. Wishing you all the best!

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