Limb Weakness: Anxiety and Autonomic Nervous System Impact - Neurology

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There is a persistent issue of weakness in the limbs?


Hello Doctor, I am a junior in college and I have anxiety disorder.
I tend to become very anxious about physical symptoms.
I take Diazepam in the morning and evening, and Clonazepam before bed.
Recently, for more than two weeks, I have been experiencing weakness in my limbs and stiffness in my shoulders and neck.
My hands and feet tremble when bent at certain angles that require effort.
I have seen a neurologist, had blood tests for thyroid function which came back normal, and underwent nerve conduction studies that were also normal.
Could the weakness in my limbs be caused by anxiety disorder and autonomic nervous system dysregulation? How can I break the vicious cycle of anxiety symptoms exacerbating my physical symptoms?

Chen Tongxue, 20~29 year old female. Ask Date: 2022/11/15

Dr. Jiang Junyi reply Neurology


Hello, Student Chen:
You mentioned that "for more than two weeks, there has been sudden weakness in the limbs and stiffness in the shoulders and neck, with shaking occurring when bending the arms and legs to a point of exertion." It may be necessary to first consider the symptoms of hyperventilation.
Hyperventilation can lead to a decrease in carbon dioxide levels in the blood, resulting in an increase in pH, which can trigger systemic reactions and symptoms.
Commonly observed symptoms include vasoconstriction and hypocalcemia.

Reduced blood flow to the brain due to vasoconstriction can cause dizziness, numbness (especially around the lips and upper limbs), and weakness.
In more severe cases, symptoms may escalate to agitation, hallucinations, and even seizures or fainting.
Hypocalcemia can lead to muscle twitching and spasms in the hands and feet.

When carbon dioxide levels are too low, patients often feel short of breath, and excessive breathing can result in chest pain.
Rapid breathing through the mouth can cause dry mouth, and sometimes air may enter the gastrointestinal tract, leading to symptoms such as bloating and belching.

I recommend that you consult a neurologist to discuss further examination and treatment.
Thank you for your inquiry, and feel free to reach out with any related questions! Wishing you good health and peace.
Dr.
Jiang Junyi, Neurology, Taoyuan Hospital

Reply Date: 2022/11/15

More Info


Hello! It's understandable that you're feeling anxious about your physical symptoms, especially since you have a history of anxiety disorder. The symptoms you describe—limb weakness, stiffness in your shoulders and neck, and trembling when exerting yourself—can indeed be influenced by anxiety and autonomic nervous system dysregulation.

Anxiety can manifest in various physical symptoms, often referred to as somatic symptoms. These can include muscle tension, weakness, and tremors. When you're anxious, your body goes into a "fight or flight" mode, which activates the sympathetic nervous system. This can lead to increased muscle tension and a heightened state of alertness, which might explain the stiffness and trembling you experience when trying to exert yourself physically.
The autonomic nervous system (ANS) is divided into two main branches: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS). The SNS prepares the body for stressful situations, while the PNS promotes relaxation and recovery. In individuals with anxiety disorders, there can be an imbalance in this system, leading to symptoms like those you're experiencing.
Your normal nerve conduction studies and thyroid function tests are reassuring and suggest that there may not be a primary neurological or endocrine cause for your symptoms. However, the interplay between anxiety and physical symptoms can create a vicious cycle. When you feel weak or experience tremors, it can heighten your anxiety, which in turn exacerbates the physical symptoms. This cycle can be challenging to break.

To address your concerns and help manage your anxiety and its physical manifestations, consider the following strategies:
1. Cognitive Behavioral Therapy (CBT): This is a highly effective form of therapy for anxiety disorders. It helps you identify and change negative thought patterns and behaviors that contribute to your anxiety.

2. Mindfulness and Relaxation Techniques: Practices such as mindfulness meditation, deep breathing exercises, and progressive muscle relaxation can help calm your nervous system and reduce anxiety.

3. Regular Physical Activity: Engaging in regular exercise can help reduce anxiety and improve your overall physical health. Activities like yoga or tai chi can be particularly beneficial as they combine physical movement with mindfulness.

4. Medication Management: Since you are already on medications like Escitalopram (Lexotan) and Clonazepam (Klonopin), it's essential to maintain open communication with your prescribing physician about your symptoms. They may need to adjust your medication or explore additional options.

5. Healthy Lifestyle Choices: Ensure you are getting adequate sleep, eating a balanced diet, and staying hydrated. These factors can significantly impact your mood and physical well-being.

6. Support Systems: Connecting with friends, family, or support groups can provide emotional support and reduce feelings of isolation.

7. Limit Stimulants: Reducing caffeine and other stimulants can help decrease anxiety levels and improve your overall sense of well-being.

It's important to remember that recovery from anxiety and its physical symptoms is a process that takes time. Be patient with yourself and seek support when needed. If your symptoms persist or worsen, consider revisiting your healthcare provider for further evaluation and support. Your health and well-being are paramount, and there are effective strategies to help you manage both your anxiety and its physical manifestations.

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