the Interaction Between Birth Control Pills and Antibiotics - Obstetrics and Gynecology

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Birth control pills and antibiotics?


Hello, doctor.
I would like to ask about adjusting my menstrual cycle with birth control pills.
I originally planned to delay my period for about two months, so I took the first pack of 24 active pills and skipped the 4 placebo pills to start the second pack directly.
During the second week of the second pack, I experienced respiratory symptoms and took erythromycin (250 mg, 2 tablets twice a day) for two days.
On Wednesday of the third week, I started having brown discharge, which turned into red bleeding two days later.
It has now been 9 days; the bleeding is not heavy but has not changed in volume.
Does this count as a period? I am concerned about prolonged bleeding.
I have not stopped taking the birth control pills during this time.
Should I continue to take the placebo pills after finishing the second pack of active pills and then start the third pack?

luma, 40~49 year old female. Ask Date: 2022/11/20

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, you should start taking the next pack of birth control pills on the fifth day after your menstrual period begins.
Wishing you good health!

Reply Date: 2022/11/20

More Info


When it comes to the interaction between birth control pills and antibiotics, it's essential to understand how these medications work and their potential effects on each other. Birth control pills, particularly combination pills that contain both estrogen and progestin, are designed to prevent ovulation and regulate menstrual cycles. Antibiotics, on the other hand, are used to treat bacterial infections.

One common concern is whether antibiotics can reduce the effectiveness of birth control pills. While some antibiotics, particularly rifampin and rifabutin, are known to decrease the effectiveness of hormonal contraceptives, most other antibiotics, including erythromycin, do not have this effect. Erythromycin is a macrolide antibiotic that is often used to treat respiratory infections and is not associated with a significant reduction in the efficacy of birth control pills.

In your case, you mentioned taking erythromycin for two days while on the second pack of your birth control pills. Since erythromycin is not one of the antibiotics that interfere with hormonal contraceptives, it is unlikely that it affected the effectiveness of your birth control during that time.

The occurrence of brown discharge followed by red bleeding after starting the second pack of pills could be attributed to several factors. It is not uncommon for women to experience breakthrough bleeding or spotting, especially when they are adjusting to a new birth control regimen or if they skip the placebo pills. This can happen due to hormonal fluctuations as your body adapts to the continuous intake of hormones without a break for a period.

Given that you have been taking the pills continuously without a break, the bleeding you are experiencing may not necessarily indicate the start of your menstrual period. Instead, it could be a response to the hormonal changes induced by the birth control pills. If the bleeding persists or becomes heavier, it is advisable to consult with your healthcare provider to rule out any underlying issues and to discuss your concerns.

As for your question about whether to continue taking the pills after finishing the second pack, it is generally recommended to continue taking the active pills as prescribed. If you are experiencing breakthrough bleeding, it is still important to complete the pack. After finishing the second pack, you can decide whether to take the placebo pills or continue with a third pack based on your healthcare provider's advice and your personal preferences.

In summary, while antibiotics can interact with certain birth control pills, erythromycin is not one of them. The bleeding you are experiencing may be a normal side effect of the hormonal changes from the birth control pills. If you have any concerns about the bleeding or the effectiveness of your birth control, it is best to consult with your healthcare provider for personalized advice and guidance. They can help you determine the best course of action based on your specific situation and health needs.

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