Syphilis Recurrence During Pregnancy: Risks and Breastfeeding Concerns - Urology

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Syphilis Issues


Hello Doctor: During the late stage of pregnancy, I tested positive for syphilis for the second time, and the result showed a relapse.
After treatment, the titer decreased to 1:8.
Four months after giving birth, I went for a follow-up test, and the result increased to 1:16 again.
Is it safe to breastfeed? I'm very worried about transmitting it to my baby.
I have been monitoring my syphilis status for many years without any relapse; why did it recur during the late stage of pregnancy? After treatment, why did it relapse again after giving birth? Could it be due to weakened immunity?

Xiao Zi, 30~39 year old female. Ask Date: 2022/12/02

Dr. Du Shixi reply Urology


Hello: Please discuss with a pediatrician.
From what I understand, it is not contagious, but due to your unstable levels, if there are any concerns, it is best to avoid breastfeeding.
Additionally, syphilis can show a rise in levels within a few years after transmission, which may require further treatment.
Therefore, regular follow-up is necessary.
Wishing you good health.

Reply Date: 2022/12/02

More Info


Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. It can have significant implications during pregnancy, both for the mother and the fetus. Understanding the recurrence of syphilis during pregnancy and the associated risks is crucial for managing the health of both the mother and the newborn.

Firstly, it is important to note that syphilis can be asymptomatic, and many individuals may not be aware of their infection status. During pregnancy, hormonal changes and alterations in the immune system can lead to a resurgence of the infection, even if it had been previously treated. This is particularly concerning in the later stages of pregnancy, as untreated syphilis can lead to serious complications, including stillbirth, premature birth, and congenital syphilis in the newborn.

In your case, the recurrence of syphilis during the late stages of pregnancy, as indicated by the increase in titers from 1:8 to 1:16, raises concerns. The rise in titers could be due to several factors, including inadequate treatment, reinfection, or the natural fluctuations of the immune response during pregnancy. It is also possible that the stress on the immune system during pregnancy could contribute to the resurgence of the infection.

Regarding breastfeeding, the Centers for Disease Control and Prevention (CDC) states that mothers with syphilis can breastfeed as long as they are receiving appropriate treatment and their infection is under control. However, it is critical to ensure that the mother is treated effectively and that there is no active lesion on the breast, as this could pose a risk of transmission to the infant. Given your situation, it is essential to consult with your healthcare provider to determine the best course of action regarding breastfeeding and to ensure that both you and your baby are monitored closely.

The treatment for syphilis typically involves antibiotics, with penicillin being the most commonly used. If you have been treated and your titers have decreased, it is essential to follow up with your healthcare provider for regular testing to monitor your syphilis status. If there is any indication of reinfection or treatment failure, further evaluation and treatment may be necessary.

In terms of your concerns about the recurrence of syphilis postpartum, it is important to maintain regular check-ups with your healthcare provider. Factors such as stress, changes in lifestyle, and immune system fluctuations can all impact your susceptibility to infections. Additionally, if you have a history of syphilis, it is crucial to practice safe sex and communicate with your partner(s) about STI testing and treatment.

In summary, while syphilis can recur during pregnancy, effective treatment and monitoring can help manage the risks associated with the infection. Breastfeeding is generally safe if the infection is under control, but it is vital to consult with your healthcare provider for personalized advice. Regular follow-ups and open communication with your healthcare team will be key in ensuring the health and safety of both you and your baby.

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