Mental Health: Questions About Anxiety and Medication Effects - Psychiatry

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Hello, Doctor.
I'm uncertain whether I'm sick or just experiencing a poor mindset, likely due to high stress that makes me easily anxious.
I'm not sure if my level of anxiety is within a normal range, but I feel completely fine when there is no stress.

1.
If I were sick, shouldn't I feel abnormal every day?
2.
I would like to ask if taking a low dose of medication for a long time could result in a situation where what was originally normal becomes abnormal?
3.
I also came across an article (https://goodmood.com.tw/what-antidepressant-do-people/) mentioning that monkeys without depression showed a reduction in the volume of the anterior cingulate cortex and hippocampus after receiving a daily dose of the SSRI antidepressant Lexapro (equivalent to humans taking the medication continuously for five years).
I want to know if taking this medication could cause my hippocampus to shrink.
I apologize for asking so many questions, but I would really appreciate your insights.
Thank you very much!

Qq, 20~29 year old female. Ask Date: 2022/12/28

Dr. Wu Enliang reply Psychiatry


1.
If someone is ill, shouldn't they be abnormal every day? A: Not necessarily.

2.
I would like to ask if taking low-dose medication for a long time could result in abnormal conditions that were originally normal? A: I do not understand this question.

3.
I saw an article (https://goodmood.com.tw/what-antidepressant-do-people/) mentioning that daily doses of Lexapro, an SSRI antidepressant, were administered to monkeys for the equivalent of five years.
In monkeys without depression, there was a simultaneous reduction in the volume of the anterior cingulate cortex and hippocampus.
I want to know if taking this medication will cause my hippocampus to shrink? A: Humans are not monkeys, so it should not be extrapolated to humans, right? Dr.
Wu Enliang.

Reply Date: 2022/12/28

More Info


Understanding mental health, particularly in the context of anxiety and medication effects, is a complex and nuanced topic. Your concerns about whether you are experiencing a mental health issue or simply reacting to stress are valid and common. Let's address your questions one by one, while also providing some additional context and information.

1. Isn't it true that if someone is sick, they should feel abnormal every day?
Mental health conditions can manifest in various ways, and not everyone experiences symptoms consistently. For instance, anxiety disorders can fluctuate in intensity. Some individuals may feel completely normal during low-stress periods and only experience symptoms when under pressure. This variability can make it challenging to identify whether one is "sick" or simply reacting to situational stress. It's essential to recognize that mental health is not always a constant state; it can be influenced by external factors like stress, environment, and personal circumstances.

2. Could long-term use of low-dose medication lead to the emergence of abnormal symptoms?
Long-term use of any medication, including low-dose antidepressants or anxiolytics, can have varying effects on individuals. While many people benefit from these medications without significant side effects, others may experience changes in their mental or physical health over time. It's crucial to have regular check-ins with your healthcare provider to monitor your response to medication. If you notice any new or worsening symptoms, discussing these with your doctor is vital. They can help determine whether the medication is contributing to these changes or if they are part of an underlying condition.

3. Concerns about the effects of SSRIs on brain structure, such as hippocampal shrinkage.
The study you referenced raises important questions about the long-term effects of SSRIs on brain structure. While some research has suggested that chronic use of SSRIs may be associated with changes in brain volume, particularly in areas like the hippocampus, the relationship is not straightforward. The hippocampus is involved in memory and emotional regulation, and changes in its size can be influenced by various factors, including stress and depression itself. Importantly, the benefits of SSRIs in managing depression and anxiety often outweigh potential risks, especially when monitored by a healthcare professional. If you have concerns about long-term medication use, it’s essential to discuss these with your doctor, who can provide personalized advice based on your health history and current situation.

In addition to medication, consider integrating other therapeutic approaches into your treatment plan. Cognitive-behavioral therapy (CBT) is an effective treatment for anxiety and can help you develop coping strategies to manage stress and anxiety symptoms. Lifestyle changes, such as regular exercise, a balanced diet, and adequate sleep, can also significantly impact your mental health.

Lastly, it’s important to remember that asking questions and seeking clarity about your treatment is not only acceptable but encouraged. Mental health is a vital aspect of overall well-being, and being proactive about your health is a positive step. If you feel comfortable, consider discussing your concerns with a mental health professional who can provide tailored guidance and support.

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