Low Urinary Creatinine Levels: What It Means for Kidney Health - Internal Medicine

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Questions about creatinine test values?


Hello Doctor Wu: I recently received my test results.
The microalbumin level is 1.7, the serum creatinine level is 0.71 [0.72-1.18], and the urinary creatinine level is 44.2 [60-250].
I would like to ask if the urinary creatinine level being significantly below the reference range indicates a potential kidney issue?

Jimmy, 20~29 year old female. Ask Date: 2023/01/07

Dr. Wu Hongjie reply Internal Medicine


The serum creatinine level is 0.71, while the standard range is 0.72-1.18, indicating it is not significantly low.
Conditions such as insufficient muscle mass or inadequate protein intake may contribute to this situation.
For urinary creatinine, a 24-hour collection is necessary for accurate measurement; a single test showing low levels may be due to incomplete urine collection, the use of diuretics, or other medications that inhibit creatinine excretion, as well as being underweight.
Wishing you good health.

Reply Date: 2023/01/07

More Info


Understanding low urinary creatinine levels can be quite complex, especially when interpreting them in the context of kidney health. In your case, the urinary creatinine level of 44.2 mg/dL is indeed below the reference range of 60-250 mg/dL. However, it is essential to consider several factors before concluding that this indicates a kidney problem.

Firstly, urinary creatinine levels can be influenced by various factors, including hydration status, muscle mass, and dietary protein intake. A low urinary creatinine level may suggest that the urine sample was diluted, possibly due to excessive fluid intake prior to the test. If a person has been drinking a lot of water, it can lead to a lower concentration of creatinine in the urine. Additionally, individuals with lower muscle mass or those who consume a low-protein diet may also exhibit lower urinary creatinine levels.
In your case, the blood creatinine level of 0.71 mg/dL falls within the normal range (0.72-1.18 mg/dL), which suggests that your kidneys are functioning adequately in filtering creatinine from the blood. This is an important indicator because it shows that the kidneys are still able to perform their primary function of excreting waste products.
Moreover, urinary creatinine levels are often assessed in conjunction with other tests, such as microalbumin levels, to evaluate kidney function more comprehensively. In your report, the microalbumin level is 1.7 mg/L, which is within the normal range. This is a positive sign, as elevated microalbumin levels can indicate early kidney damage, particularly in individuals with diabetes or hypertension.

It is also crucial to consider the method of urine collection. A single urine sample may not provide a complete picture of kidney function. A 24-hour urine collection is often recommended for a more accurate assessment of urinary creatinine excretion. This method accounts for variations in urine concentration throughout the day and provides a better understanding of kidney function.

If you are concerned about your kidney health, it is advisable to discuss these results with your healthcare provider. They can help interpret the results in the context of your overall health, medical history, and any symptoms you may be experiencing. They may also recommend further testing, such as a 24-hour urine collection or additional blood tests, to monitor kidney function more closely.

In summary, while a low urinary creatinine level can raise questions about kidney health, it is essential to consider the broader context, including hydration status, muscle mass, dietary factors, and accompanying test results. Your blood creatinine level being within the normal range is reassuring, and the microalbumin level also suggests that there may not be significant kidney damage at this time. Regular monitoring and open communication with your healthcare provider will be key in managing your kidney health effectively.

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