Myocardial Perfusion Scans: Insights on Ischemia and Treatment Options - Cardiology

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Echocardiogram


Hello Dr.
He, I previously inquired about the nuclear medicine report for the Tl-201 Myocardial Perfusion Scan: The patient has recently experienced chest tightness.
A Tl-201 myocardial perfusion scan was performed with dipyridamole stress.
Dipyridamole 0.57 mg/kg was administered intravenously over 4 minutes.
Tl-201 2 mCi was injected 2 minutes after pharmacological stress.
Images were acquired 5 minutes and 4 hours after injection using SPECT.
The images were reconstructed using iterative reconstruction techniques and displayed in multiple transaxial planes and 3D images.

1.
Anterior wall: Normal uptake.

2.
Septal wall: Abnormal uptake; reversible.

3.
Inferior wall: Abnormal uptake; partially reversible.

4.
Lateral wall: Normal uptake.

5.
Apical wall: Normal uptake.

Lung uptake was normal.
The L/H ratio was 0.37 (stress) and 0.31 (rest).

NUCLEAR CARDIOLOGY DIAGNOSIS:
1.
Mild ischemia in the apical-inferior and basal-anteroseptal walls.

2.
Stress LVEF: 70%, Rest LVEF: 70%.

Subsequent tests included echocardiography and exercise electrocardiogram showing dilated left atrium with normal wall motion and adequate left ventricular systolic performance, LVEF 72%, grade I impaired left ventricular relaxation, with lead III and AVF showing slowly upsloping ST depression positive for ischemia.

Currently, the patient is taking 5 mg of Concor and Beraprost.
Should the treatment be managed with medication, or would other therapies be more appropriate? Thank you!

Ming, 40~49 year old female. Ask Date: 2023/01/17

Dr. He Dongjin reply Cardiology


Hello, my suggestion is to manage your condition with medication.
Changhua Hospital cares about you.

Reply Date: 2023/01/17

More Info


Understanding myocardial perfusion scans is crucial for assessing the presence and severity of ischemia, which can lead to coronary artery disease (CAD) and other cardiovascular complications. The Tl-201 myocardial perfusion scan you underwent, particularly with the use of dipyridamole as a pharmacological stress agent, provides valuable insights into the blood flow to your heart muscle during stress and at rest.

From your report, it appears that there is mild ischemia in the apical-inferior and basal-anteroseptal walls, with the septal wall showing abnormal uptake that is reversible. This indicates that during stress, these areas of the heart muscle are not receiving adequate blood flow, which can be a sign of underlying coronary artery disease. The fact that the uptake is reversible suggests that the ischemia is not permanent and that the heart muscle may still be viable, but it does require further evaluation and management.

Your left ventricular ejection fraction (LVEF) is reported as 70% during both stress and rest, which is within normal limits. This indicates that your heart is pumping effectively, but the presence of ischemia in specific regions is concerning and warrants further investigation. The normal lung uptake and the L/H ratios suggest that there is no significant congestion or heart failure at this time.

In terms of treatment options, the medications you are currently taking, such as Concor (bisoprolol) and Beraprost, are typically used to manage symptoms and improve heart function. Bisoprolol is a beta-blocker that can help reduce heart rate and myocardial oxygen demand, while Beraprost is a prostacyclin analogue that can improve blood flow. However, medication alone may not be sufficient if there are significant blockages in the coronary arteries.

Given your symptoms of chest tightness and the findings from your myocardial perfusion scan, it may be prudent to consider further diagnostic procedures. A coronary angiogram (heart catheterization) could provide a more definitive assessment of the coronary arteries and identify any significant blockages that may require intervention, such as angioplasty or stenting. This is particularly important if your symptoms persist or worsen, as timely intervention can prevent more serious complications like myocardial infarction (heart attack).

Additionally, lifestyle modifications should not be overlooked. These include adopting a heart-healthy diet, engaging in regular physical activity (as tolerated), quitting smoking if applicable, and managing stress. These changes can significantly impact your overall cardiovascular health and may improve your symptoms.

In summary, while your current medications are a good start, the presence of ischemia on your myocardial perfusion scan suggests that further evaluation is necessary. A discussion with your cardiologist about the potential need for a coronary angiogram and a comprehensive management plan, including lifestyle changes, is recommended. This approach will help ensure that any underlying issues are addressed and that you receive the most appropriate care for your condition.

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