Impact of Sleep Medications on Open-Angle Glaucoma Management - Ophthalmology

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Hello, doctor.
I would like to ask you about my condition.
I have mild open-angle glaucoma, which is considered ocular hypertension.
Currently, I am not using any eye drops and am in an observational state without a definitive diagnosis.
I take a sleeping pill, Alprazolam, every night to help with sleep.
However, I noticed on the medication label that it states: "1.
Alprazolam is contraindicated in patients allergic to benzodiazepines.
2.
This medication may be used in patients with open-angle glaucoma who are receiving appropriate treatment, but it is contraindicated in those with angle-closure glaucoma." Since I am not currently receiving treatment with glaucoma eye drops, can I continue taking it? Or would it be better to switch to another medication, such as Zolpidem, which does not affect eye pressure? Thank you for your time.

R, 30~39 year old female. Ask Date: 2023/01/18

Dr. Cai Wenyuan reply Ophthalmology


According to what you said, it should not have an impact.
I recommend discussing it with the attending physician.

Reply Date: 2023/01/18

More Info


When it comes to managing open-angle glaucoma, the use of sleep medications, particularly benzodiazepines like Alprazolam (commonly known as Xanax), raises important considerations. Open-angle glaucoma is a condition characterized by increased intraocular pressure (IOP) that can lead to optic nerve damage and vision loss if not properly managed. While you mentioned that you are currently under observation and not on any topical medications for glaucoma, it is crucial to understand the implications of using sleep medications in this context.

Benzodiazepines, including Alprazolam, are known to have sedative effects that can help with anxiety and sleep disturbances. However, they can also have side effects that may indirectly affect eye health. For instance, benzodiazepines can cause sedation and may lead to decreased alertness, which could potentially impact your ability to monitor your symptoms or manage your condition effectively. Additionally, there is a concern that these medications can lead to increased intraocular pressure in some patients, particularly those with a predisposition to glaucoma.

The warning you noted regarding the use of Alprazolam in patients with open-angle glaucoma is particularly relevant. While it is generally considered safe for patients with open-angle glaucoma who are under appropriate treatment, the lack of treatment in your case raises a red flag. The concern is that even if you are not currently experiencing elevated IOP, the use of Alprazolam could potentially exacerbate any underlying issues, especially if your condition progresses or if you develop sensitivity to the medication.

In contrast, medications like Zolpidem (commonly known as Ambien) or other non-benzodiazepine sleep aids may be safer alternatives for individuals with glaucoma. These medications work differently and are less likely to affect intraocular pressure. However, it is essential to consult with your healthcare provider before making any changes to your medication regimen. They can provide personalized advice based on your specific health status, the severity of your glaucoma, and any other medications you may be taking.

Moreover, it is crucial to address the underlying causes of your sleep disturbances. Anxiety, stress, and other psychological factors can significantly impact sleep quality. Cognitive-behavioral therapy (CBT) for insomnia, relaxation techniques, and lifestyle modifications may provide effective alternatives to pharmacological interventions. These approaches can help improve sleep without the potential risks associated with long-term use of sleep medications.

In summary, while you may currently be using Alprazolam for sleep, it is advisable to discuss your situation with your ophthalmologist or primary care physician. They can help assess your glaucoma status, evaluate the risks associated with your current medication, and consider alternative treatments that may be safer for your eye health. Regular monitoring of your intraocular pressure and overall eye health is essential, especially as you navigate the complexities of managing both sleep issues and glaucoma.

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