Why do liver tumors shrink?
In early November 2022, a company health check revealed that I have mild fatty liver.
In mid-November 2022, a hospital examination found a liver tumor measuring 1.5 x 1.0 cm (hypoechoic).
The doctor immediately arranged for an abdominal MRI (with contrast), which showed no abnormalities (performed in early December 2022).
A few days ago (on February 2, 2023), I returned for a follow-up ultrasound, and the same location showed a liver tumor that has decreased in size (1.0 x 0.9 cm).
1.
Is there a possibility that this is malignant?
2.
Is this related to my three months of starting to exercise and controlling my diet (intermittent fasting 16:8)? (From mid-November last year to February this year, my weight decreased from nearly 70 kg to 66 kg, successfully losing over 3 kg.)
3.
Why was there no abnormality detected in the MRI initially? (The report stated that the liver parenchyma was homogeneous.)
P.S.
I have no history of hepatitis B or C, do not drink alcohol or smoke, and my blood tests for CEA, AFP, and CA 19-9 in mid-November 2022 were all normal.
Zhan, 30~39 year old female. Ask Date: 2023/02/06
Dr. Hu Guozheng reply Gastroenterology and Hepatology
Hello, patients with chronic hepatitis B, hepatitis C, and cirrhosis are at high risk for liver cancer and require regular monitoring.
If there is a suspected liver tumor on abdominal ultrasound, further confirmation should be done through computed tomography (CT), magnetic resonance imaging (MRI), or biopsy.
It is advisable to discuss the examination results with your attending physician.
Thank you.
Reply Date: 2023/02/06
More Info
The shrinkage of your liver tumor from 1.5 x 1.0 cm to 1.0 x 0.9 cm is certainly a positive development, and it raises several important questions regarding its nature, the impact of lifestyle changes, and the diagnostic processes involved.
1. Possibility of Malignancy: The fact that the tumor has decreased in size is encouraging, but it does not completely rule out the possibility of malignancy. Tumors can be benign (non-cancerous) or malignant (cancerous), and certain benign tumors can also change in size. Given that you have no history of hepatitis B or C, no alcohol consumption, and normal tumor markers (CEA, AFP, CA199), the likelihood of a malignant tumor is reduced, but not entirely eliminated. It is essential to continue monitoring the tumor with regular imaging studies and consultations with your healthcare provider to determine its nature over time.
2. Impact of Lifestyle Changes: Your commitment to exercise and dietary control, including intermittent fasting (168), likely played a significant role in your weight loss and overall liver health. Weight loss can positively affect liver conditions, particularly fatty liver disease, which you mentioned having. Reducing body weight can decrease liver fat, improve liver function, and potentially influence the behavior of liver tumors. Studies have shown that lifestyle modifications, including diet and exercise, can lead to improvements in liver health and may even contribute to the reduction of certain types of liver tumors. Your weight loss from nearly 70 kg to 66 kg, while seemingly modest, can have a substantial impact on liver health, especially if it is sustained.
3. MRI Findings: The MRI report indicating "homogeneous liver parenchyma" suggests that there were no significant abnormalities detected at that time. It is possible that the tumor was either too small to be detected or that it was not visible due to the imaging technique used. MRI is a highly sensitive imaging modality, but it can sometimes miss small lesions, especially if they are not enhancing or if they are isoechoic to the surrounding liver tissue. The ultrasound performed later may have been more sensitive to detecting changes in the tumor's characteristics, leading to the identification of the tumor that had previously gone unnoticed.
In summary, the shrinkage of your liver tumor is a positive sign, and your lifestyle changes may have contributed to this improvement. However, it is crucial to maintain regular follow-ups with your healthcare provider to monitor the tumor's status and ensure that any potential issues are addressed promptly. Regular imaging and blood tests will help in assessing the tumor's behavior and determining the appropriate management strategy moving forward. Always consult with your healthcare provider for personalized advice and recommendations based on your specific health situation.
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