Declining GFR: Is Your Kidney Health at Risk? - Internal Medicine

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Understanding the implications of declining glomerular filtration rate (GFR) is crucial for assessing kidney health. In your case, you have observed a decrease in your eGFR from approximately 120 to 99, and then to 94 over the span of a year. This decline is indeed noteworthy and warrants further discussion.

Firstly, it's important to understand what eGFR represents. The estimated glomerular filtration rate is a measure of how well your kidneys are filtering waste from your blood. A normal eGFR is typically above 90 mL/min/1.73 m², and values below this threshold can indicate varying degrees of kidney dysfunction. While fluctuations in eGFR can occur due to various factors, a consistent downward trend, especially to levels below 90, should be taken seriously.

In your case, the decline from 99 to 94 suggests a potential reduction in kidney function. While it is common for eGFR values to vary slightly due to hydration status, dietary changes, or acute illnesses, a significant and sustained decrease could indicate underlying kidney issues. Factors such as medications, especially those affecting renal function, can also play a role. You mentioned taking medication for endometriosis (likely a hormonal treatment), which can sometimes have side effects that impact kidney function. It is essential to consult with your healthcare provider regarding the specific medication you are taking, as some drugs can lead to changes in kidney function.

Moreover, the presence of other health conditions, such as hypertension or diabetes, can also contribute to declining kidney function. If you have any history of these conditions, it would be prudent to monitor them closely. Additionally, lifestyle factors such as diet, hydration, and physical activity can significantly influence kidney health. Maintaining a balanced diet low in sodium and processed foods, staying well-hydrated, and engaging in regular exercise can help support kidney function.

Regarding your concern about whether stopping the medication will lead to an improvement in your eGFR, this is a complex question. Some patients may experience a return to baseline kidney function after discontinuing certain medications, while others may not. It is crucial to have a thorough discussion with your healthcare provider about the risks and benefits of continuing or stopping your medication, as well as the potential impact on your kidney health.

In conclusion, while a decline in eGFR can be concerning, it is essential to approach this issue holistically. Regular monitoring of kidney function, discussing any medications with your healthcare provider, and making lifestyle adjustments can all contribute to better kidney health. If your eGFR continues to decline or if you experience any symptoms such as swelling, changes in urination, or fatigue, it is vital to seek further evaluation from a nephrologist or your primary care physician. Early intervention can often prevent more severe complications and help maintain kidney function over time.