Persistent Hiccups: When to Seek Medical Advice - Gastroenterology and Hepatology

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Chronic hiccups


Hello Doctor, I have been experiencing hiccups since December of last year.
Initially, they occurred only after meals, but later they became more frequent and unpredictable, happening upon waking and when I'm hungry.
Each episode consists of two to three hiccups in a row.
The hiccups after eating have a food taste, while those when I'm hungry or upon waking have no unusual odor.
I have seen both Western and Chinese medicine practitioners twice, but there has been no improvement.
A Western doctor performed an abdominal ultrasound, which showed that my diaphragm and other organs are normal with no lesions, but my stomach is filled with gas.
Aside from the hiccups, I have no other discomfort.
Should I consider getting an endoscopy? I am very concerned about the possibility of stomach cancer and would like to hear your opinion.

q, 10~19 year old female. Ask Date: 2023/02/19

Dr. Chen Shidian reply Gastroenterology and Hepatology


There should be no related issues; it is mostly caused by peristaltic digestion.
There may also be subconscious habits of belching.
It is advisable to eat small, frequent meals, minimize talking during meals, and take a walk after eating instead of sitting for long periods.

Reply Date: 2023/02/19

More Info


Persistent hiccups can be a frustrating and uncomfortable experience, especially when they last for an extended period. Hiccups are involuntary contractions of the diaphragm, followed by a sudden closure of the vocal cords, which produces the characteristic "hic" sound. While occasional hiccups are common and usually harmless, persistent hiccups—defined as lasting more than 48 hours—can sometimes indicate an underlying medical condition that requires further investigation.

In your case, it seems that your hiccup episodes started after meals and have since progressed to occurring at various times, including when you wake up and when you are on an empty stomach. The fact that you have already consulted both Western and Traditional Chinese Medicine practitioners without relief is concerning, especially since you are experiencing these symptoms consistently.

Given that you have undergone an abdominal ultrasound that showed no abnormalities in your diaphragm or other organs, and only indicated gas in your stomach, it may be time to consider further diagnostic testing, such as an upper gastrointestinal (GI) endoscopy (gastroscopy). This procedure allows a doctor to examine the lining of your esophagus, stomach, and the beginning of your small intestine using a flexible tube with a camera. It can help identify conditions such as gastritis, esophageal reflux, or even more serious issues like tumors, including gastric cancer.

Your concern about the possibility of gastric cancer is understandable, especially given the persistent nature of your symptoms. While hiccups alone are not a definitive symptom of cancer, they can be associated with various gastrointestinal disorders, including malignancies. Other symptoms to watch for include unexplained weight loss, persistent abdominal pain, changes in appetite, or any gastrointestinal bleeding. If you experience any of these symptoms, it is crucial to seek medical attention promptly.

In addition to a gastroscopy, other potential causes of persistent hiccups that your healthcare provider may consider include:
1. Gastroesophageal Reflux Disease (GERD): Acid reflux can irritate the diaphragm and lead to hiccups.

2. Nerve Irritation: The phrenic nerve, which controls the diaphragm, can be irritated by various factors, including tumors or infections.

3. Metabolic Disorders: Conditions such as diabetes or electrolyte imbalances can contribute to persistent hiccups.

4. Central Nervous System Disorders: Rarely, issues affecting the brain or spinal cord can lead to hiccups.

While waiting for your next steps, there are some home remedies you might try to alleviate hiccups, such as drinking a glass of water quickly, holding your breath, or swallowing a teaspoon of sugar. However, these methods are often temporary and may not address the underlying cause.

In conclusion, given the persistence of your symptoms and the lack of improvement with initial treatments, it is advisable to pursue further evaluation, including a gastroscopy. This will help rule out any serious conditions and guide appropriate treatment. Remember to communicate openly with your healthcare provider about your concerns, and do not hesitate to seek a second opinion if you feel it is necessary. Your health and peace of mind are paramount, and addressing these symptoms early can lead to better outcomes.

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