the Effects of Overdosing on Antimicrobial Medication - Gastroenterology and Hepatology

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Medication consultation


Recently, I have been taking antibiotics for two weeks due to gynecological issues, along with experiencing gastroesophageal reflux.
During my recent consultation, I was prescribed 40 mg of Nizatidine, but I accidentally took two pills on the first day instead of one.
I would like to know if this overdose could cause any effects.
Currently, I only have a sensation of something stuck in my throat and a rough feeling on my tongue, but I do not have any stomach pain.
Thank you very much.

Niming, 20~29 year old female. Ask Date: 2023/03/01

Dr. Chen Shidian reply Gastroenterology and Hepatology


There will be no side effects.

Reply Date: 2023/03/01

More Info


Overdosing on antimicrobial medications, such as antibiotics, can lead to a range of adverse effects, and it’s important to understand the potential implications of such an incident. In your case, you mentioned taking two doses of耐適恩 (Nafcillin) instead of the prescribed one dose. While it’s reassuring that you are not experiencing significant gastrointestinal discomfort, there are still several factors to consider regarding the effects of overdosing on antibiotics.

Firstly, the specific medication you mentioned,耐適恩 (Nafcillin), is a penicillin-type antibiotic primarily used to treat infections caused by certain bacteria. Overdosing on antibiotics can lead to various side effects, including but not limited to gastrointestinal disturbances, allergic reactions, and effects on the liver and kidneys. Common gastrointestinal side effects include nausea, vomiting, diarrhea, and abdominal pain. However, in your case, since you have not experienced any gastrointestinal pain, it is a positive sign.

One of the more serious concerns with antibiotic overdosing is the potential for allergic reactions. Symptoms can range from mild rashes to severe anaphylactic reactions, which can be life-threatening. If you notice any signs of an allergic reaction, such as difficulty breathing, swelling of the face or throat, or severe rash, you should seek immediate medical attention.

Another important aspect to consider is the impact of overdosing on the effectiveness of the antibiotic. Taking more than the prescribed dose does not necessarily increase the effectiveness of the medication against the infection. In fact, it can lead to increased side effects without providing additional therapeutic benefits. Moreover, inappropriate use of antibiotics can contribute to the development of antibiotic resistance, which is a growing public health concern. This occurs when bacteria adapt and become resistant to the effects of the medication, making future infections harder to treat.

Regarding your symptoms of a "thick tongue" and a rough feeling in your throat, these could be related to several factors. Antibiotics can disrupt the natural balance of bacteria in the mouth and throat, potentially leading to oral thrush, a fungal infection caused by an overgrowth of Candida. This condition can cause a thick, white coating on the tongue and a rough texture. If you suspect this might be the case, it would be advisable to consult your healthcare provider for an evaluation.

In conclusion, while you may not be experiencing severe side effects from the accidental overdose of耐適恩, it is essential to monitor your symptoms closely. If you experience any new or worsening symptoms, or if your throat discomfort persists, please reach out to your healthcare provider for further evaluation. Additionally, always ensure to follow the prescribed dosage instructions carefully in the future to avoid similar situations. If you have any concerns about the medications you are taking or their effects, do not hesitate to discuss them with your healthcare provider, who can provide personalized advice based on your medical history and current health status.

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