Does Antibiotic Use During Birth Control Break Affect Effectiveness? - Obstetrics and Gynecology

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Taking antibiotics during the break period of birth control pills?


I would like to ask if taking antibiotics (such as erythromycin and cefadroxil monohydrate) during my medication break for a urinary tract infection will affect the effectiveness of my birth control.
Today is the sixth day since I stopped the medication.
If it does affect the effectiveness, would the doctor recommend that I start taking it again today to quickly restore the levels in my body? Thank you!

Māo, 10~19 year old female. Ask Date: 2023/03/10

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have an impact.
Wishing you good health.

Reply Date: 2023/03/10

More Info


When it comes to the interaction between antibiotics and birth control pills, there has been a long-standing concern among women regarding the effectiveness of hormonal contraceptives when taken alongside certain antibiotics. However, the reality is more nuanced and depends on the specific medications involved.

In your case, you mentioned taking antibiotics for a urinary tract infection, specifically "優克黴素" (likely referring to "Ampicillin" or a similar antibiotic) and "cefadroxil monohydrate." It is important to note that most antibiotics do not significantly affect the effectiveness of birth control pills. The primary antibiotic that has been shown to potentially interfere with hormonal contraceptives is rifampin, which is used to treat tuberculosis. Rifampin can induce liver enzymes that metabolize hormones, thereby reducing the effectiveness of birth control pills. However, the antibiotics you mentioned, such as cefadroxil, do not have this effect.

Research indicates that while some antibiotics may alter the gut flora or the metabolism of contraceptive hormones, the clinical significance of this interaction is minimal for most commonly prescribed antibiotics. The consensus among healthcare professionals is that the majority of antibiotics, including cefadroxil and ampicillin, do not compromise the effectiveness of birth control pills.

Regarding your question about whether you should resume taking your birth control pills after a six-day break, it is generally advisable to restart your contraceptive regimen as soon as you are able. If you have missed pills during the break, you should follow the instructions provided in your birth control pill package insert. Most combination birth control pills allow for a grace period, but if you have missed more than one pill, you may need to use backup contraception (such as condoms) for a short period after resuming your pills to ensure you are protected against pregnancy.

If you are concerned about the timing of your birth control effectiveness, it is always a good idea to consult with your healthcare provider. They can provide personalized advice based on your medical history and the specific birth control method you are using. Additionally, if you have any further questions about your antibiotics or their potential interactions with your contraceptive method, your healthcare provider can clarify these concerns.

In summary, the antibiotics you mentioned are unlikely to affect the effectiveness of your birth control pills. It is safe to resume taking your contraceptive as directed, and if you have any lingering concerns, do not hesitate to reach out to your healthcare provider for further guidance. Always remember that maintaining open communication with your healthcare provider is key to managing your health effectively.

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Hello, it generally does not have an impact. Wishing you good health.

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