Combining Vaginal Suppositories and Oral Medications for Yeast Infections - Obstetrics and Gynecology

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Vaginal suppositories + oral medication


Hello, doctor.
Recently, I was diagnosed with a vaginal yeast infection, and the clinic provided me with a suppository and prescribed a three-day course of oral medication (nystatin).
Since I am taking medication to regulate my menstrual cycle and my period is expected to start in about three days, the doctor also gave me three suppositories.
Should I use the oral medication and the suppositories together for three days, or should I finish the suppositories first and then start the oral medication when my period begins? I apologize for the confusion; I forgot to ask during my visit.
Thank you for your help.

Niming, 20~29 year old female. Ask Date: 2023/03/12

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, when menstruation occurs, you should stop using the suppositories, but oral medications do not have any effect.
Wishing you good health.

Reply Date: 2023/03/12

More Info


When it comes to treating a yeast infection, the combination of vaginal suppositories and oral medications can be an effective approach. In your case, you have been prescribed a vaginal suppository and an oral medication (Nystatin) for a yeast infection, and you are wondering about the timing of these treatments, especially with your upcoming menstrual cycle.

To clarify, both the vaginal suppository and the oral medication can be used concurrently, but the timing can depend on your specific situation and the recommendations of your healthcare provider. Generally, if you have been instructed to use a vaginal suppository for three days, it is advisable to complete that course before starting the oral medication, unless otherwise directed by your physician.
The reason for this is that the suppository is designed to deliver medication directly to the site of infection, which can help alleviate symptoms more quickly. On the other hand, the oral medication works systemically, meaning it will circulate throughout your body and can help treat the infection from within.
If your menstrual cycle begins while you are using the suppository, it is typically safe to continue using it during your period. However, menstrual flow may wash out some of the medication, potentially reducing its effectiveness. If you are concerned about this, you might want to consult your healthcare provider for personalized advice.

In terms of the timing of the oral medication, if you have completed the three-day course of the suppository and your period starts, you can begin taking the oral medication as prescribed. It is essential to follow the instructions given by your healthcare provider regarding the duration and timing of both treatments.

Additionally, it is important to note that yeast infections can be recurrent, and factors such as hormonal changes, antibiotic use, and certain health conditions can contribute to their occurrence. If you find that you are experiencing frequent yeast infections, it may be beneficial to discuss this with your healthcare provider to explore potential underlying causes and preventive measures.

In summary, you can use both the vaginal suppository and the oral medication, but it is generally recommended to complete the suppository treatment first. If your period starts during this time, you can continue using the suppository, but be mindful of its effectiveness. After completing the suppository treatment, you can start the oral medication as directed. Always consult your healthcare provider for personalized advice tailored to your specific situation.

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Hello, oral medications and vaginal suppositories can be used together. If you have your period, do not use the suppository; wait until it is finished before using it again. Wishing you good health.

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