Unexplained Leg Pain: Seeking Answers for Persistent Discomfort - Neurology

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Foot pain?


Hello, doctor! I am 48 years old and I haven't fallen or twisted my ankle, but suddenly one of my legs started to hurt.
The pain (in the back of my hip) has persisted for over a month.
Physical therapy and rehabilitation have been ineffective.
Initially, I had pain in the back of one hip, but later it spread to multiple areas.
An X-ray showed that my bones, spine, and nerves are all fine, and the doctor could not identify the cause.
Currently, I am taking Vitamin B Complex, but there has been no improvement.
Could this be due to a nutritional deficiency or excess uric acid? Thank you for your response.

Christine, 40~49 year old female. Ask Date: 2023/03/18

Dr. Wu Mukhan reply Neurology


Hello, X-rays can be used to examine the bones and joints of the limbs for any issues; however, problems related to nerves, muscles, blood vessels, and soft tissues cannot be fully diagnosed using X-rays alone.
Elevated uric acid levels can lead to arthritis known as gout, which typically affects areas such as the big toe and knees, and may not align with your symptoms.
Based on your symptoms, more common causes could include sciatica or muscle strains; however, to confirm the diagnosis, it is essential to visit a hospital for further examination in order to provide targeted treatment.

Reply Date: 2023/03/18

More Info


Hello! Thank you for reaching out with your concerns regarding your unexplained leg pain. I understand how frustrating it can be to experience persistent discomfort, especially when medical evaluations have not yielded clear answers. Let’s explore some potential causes and considerations regarding your situation.

Firstly, it’s important to recognize that unexplained leg pain can arise from various sources, even when imaging studies like X-rays show no apparent abnormalities. Given that you have been experiencing pain for over a month, and it has progressed from localized discomfort in the hip area to more widespread pain, there are several factors to consider.

1. Muscle Strain or Overuse: Even without a specific injury, muscle strains can occur due to overuse or repetitive movements. If you have increased your physical activity or changed your routine recently, this could contribute to muscle fatigue and pain.

2. Nerve Compression or Irritation: Conditions such as sciatica, where the sciatic nerve is compressed or irritated, can cause pain that radiates from the lower back down the leg. This might not always show up on X-rays, as nerve issues are often better evaluated with MRI or nerve conduction studies.

3. Inflammatory Conditions: Conditions like tendinitis or bursitis can cause pain in the hip and leg area. These conditions may not always be visible on standard imaging but can be diagnosed through clinical evaluation and sometimes ultrasound.

4. Nutritional Deficiencies: You mentioned taking Vitamin B Complex. While B vitamins are essential for nerve health, deficiencies in other nutrients, such as Vitamin D, calcium, or magnesium, can also lead to muscle pain and discomfort. It may be worthwhile to have your vitamin levels checked through blood tests.

5. Uric Acid Levels: Elevated uric acid levels can lead to gout, which typically causes sudden and severe pain in the joints, often starting in the big toe. However, it can also affect other joints, including those in the legs. If you suspect this might be an issue, a blood test to check uric acid levels could be beneficial.

6. Psychosomatic Factors: Chronic pain can sometimes be exacerbated by psychological factors such as stress, anxiety, or depression. If you are experiencing emotional distress, it may be worthwhile to explore this with a mental health professional, as addressing these issues can sometimes alleviate physical symptoms.

7. Fibromyalgia: This is a condition characterized by widespread musculoskeletal pain, fatigue, and tenderness in localized areas. It can often be misdiagnosed or overlooked, especially if there are no clear signs on imaging studies.

Given the complexity of your symptoms, I recommend seeking a comprehensive evaluation from a specialist, such as a rheumatologist or a pain management specialist. They can perform a thorough assessment, including a detailed history and physical examination, and may suggest additional tests such as MRI, nerve conduction studies, or blood tests to rule out various conditions.

In the meantime, consider gentle stretching and strengthening exercises, as well as physical therapy, which may help alleviate some discomfort. Additionally, maintaining a balanced diet and staying hydrated can support overall health and potentially improve your symptoms.

I hope this information provides some clarity and direction for you. Please take care and don’t hesitate to seek further medical advice to address your ongoing pain.

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