Does Sacroiliac Joint Pain Syndrome Cause Elevated Inflammatory Markers? - Orthopedics

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Does sacroiliac joint pain syndrome cause an abnormal increase in inflammatory markers?


Hello Doctor, I have been experiencing pain in my sacroiliac joint for six months, and rehabilitation has not been effective.
After consulting a rheumatologist and undergoing some tests, I was diagnosed with ankylosing spondylitis.
However, I would like to seek opinions from other specialists, so I would like to ask Dr.
Shi about a condition I recently read about online called sacroiliac joint pain syndrome (caused by long-term poor posture, among other reasons).
I would like to know if patients with this syndrome often have elevated inflammatory markers, such as a CRP level frequently exceeding 1.5 mg/dL and an ESR often exceeding 40 mm/h? Thank you, Doctor.

Zhong, 20~29 year old female. Ask Date: 2023/03/21

Dr. Chen Bochen reply Orthopedics


Hello, the patients with sacroiliac joint pain syndrome typically do not show elevated levels of CRP or ESR.

Reply Date: 2023/03/21

More Info


Sacroiliac Joint Pain Syndrome (SIJPS) is a condition that can cause significant discomfort in the lower back and buttocks, often resulting from issues related to the sacroiliac joint, which connects the lower spine to the pelvis. This syndrome can arise from various factors, including prolonged poor posture, injury, or underlying conditions such as ankylosing spondylitis (AS), which is a type of inflammatory arthritis that primarily affects the spine and the sacroiliac joints.

In your case, you mentioned that you have been diagnosed with ankylosing spondylitis after consulting a rheumatologist. This condition is known to cause inflammation in the sacroiliac joints, which can lead to elevated inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Typically, patients with ankylosing spondylitis may present with elevated CRP levels, often exceeding 1.5 mg/dL, and ESR levels that can be significantly higher than the normal range, sometimes reaching 40 mm/h or more.

However, it is important to differentiate between SIJPS and conditions like ankylosing spondylitis. SIJPS itself, particularly when it is not associated with inflammatory arthritis, may not necessarily lead to elevated inflammatory markers. In fact, patients with SIJPS due to mechanical issues or posture-related problems often have normal inflammatory markers. The inflammation seen in conditions like ankylosing spondylitis is systemic and can lead to the elevation of these markers, while SIJPS may not.

In your inquiry, you specifically asked whether patients with SIJPS typically have elevated inflammatory markers. The answer is that while some patients with SIJPS may have elevated markers due to associated conditions or if there is an inflammatory component, many do not. If your inflammatory markers are elevated, it may suggest an underlying inflammatory condition, such as ankylosing spondylitis, rather than SIJPS alone.

It is also worth noting that the management of SIJPS often involves physical therapy, pain management, and sometimes corticosteroid injections to reduce inflammation. If conservative measures such as rehabilitation have not provided relief, further evaluation by a specialist may be warranted to explore other treatment options or to reassess the diagnosis.

In conclusion, while SIJPS itself may not cause elevated inflammatory markers, the presence of elevated CRP and ESR in your case suggests that there may be an underlying inflammatory condition, such as ankylosing spondylitis, contributing to your symptoms. It is crucial to continue working with your healthcare provider to monitor your condition and adjust your treatment plan as necessary. If you have further concerns or if your symptoms persist, seeking a second opinion or additional diagnostic testing may be beneficial to ensure an accurate diagnosis and effective management of your pain.

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