Do All Ankylosing Spondylitis Patients Experience Morning Stiffness? - Internal Medicine

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Do patients with ankylosing spondylitis always experience morning stiffness?


Hello Doctor, I am 20 years old, HLA-B27 positive, and MRI of the sacroiliac joints shows inflammation (the following is an excerpt from my MRI report: R/I chronic sacroiliitis; axial spondyloarthropathy is highly suggested...
IMP: Bilateral sacroiliitis, more severe on the left side, R/O axial spondyloarthropathy).
My CRP is around 1.8 mg/dL, and my ESR is around 30.
Before my diagnosis, I underwent physical therapy for nearly six months for sacroiliac joint pain, but it has not completely resolved.
My rheumatologist has diagnosed me with ankylosing spondylitis, but I have never experienced morning stiffness either before or after the diagnosis.
The only pain I have is in the sacroiliac joint, which does not improve with activity during the day.
I am somewhat skeptical about whether I truly have ankylosing spondylitis, so I would like to ask the doctor: 1) Do all patients with ankylosing spondylitis experience morning stiffness? Does the pain in the sacroiliac joints of ankylosing spondylitis patients always improve with activity? 2) Am I likely to have ankylosing spondylitis? Thank you, Doctor.

Hao, 20~29 year old female. Ask Date: 2022/05/30

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your question.
Here are my responses:
1) Do patients with ankylosing spondylitis always experience morning stiffness? Does the pain in the sacroiliac joints of ankylosing spondylitis patients always improve after activity? --> The likelihood of experiencing morning stiffness is quite high, so it would be somewhat unusual not to have it.
In cases of more severe sacroiliitis, even exercise may not provide relief, and medication may be necessary.
Given your elevated inflammatory markers, I recommend starting medication for a period of time, along with exercise, which may lead to further improvement.
2) Should I assume that I have ankylosing spondylitis? --> Based on your MRI findings, your age, and your elevated inflammatory markers, I believe it is likely.

Best regards from the Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare.

Reply Date: 2022/05/30

More Info


Ankylosing Spondylitis (AS) is a chronic inflammatory disease primarily affecting the spine and the sacroiliac joints, which can lead to pain and stiffness. One of the hallmark symptoms of AS is morning stiffness, but it is important to note that not all patients experience this symptom.
1) Do all Ankylosing Spondylitis patients experience morning stiffness?
Morning stiffness is indeed a common symptom among AS patients, but it is not universal. Some individuals may experience stiffness that improves with movement, while others may not have significant morning stiffness at all. The absence of morning stiffness does not rule out the diagnosis of AS. Each patient's experience can vary widely, and symptoms can manifest differently based on individual factors, including the severity of the disease, the presence of other conditions, and personal pain thresholds.
In your case, despite being diagnosed with AS and having imaging evidence of sacroiliitis, you report no morning stiffness. This could suggest that your particular manifestation of AS is atypical, or that other factors may be influencing your symptoms. It is crucial to communicate these observations with your rheumatologist, as they can provide insights into your specific situation and adjust your treatment plan accordingly.

2) Does pain in the sacroiliac joints in AS patients always improve with activity?
While many AS patients find that their pain improves with movement, this is not a definitive rule. Some individuals may experience persistent pain in the sacroiliac joints regardless of activity. The pain can be influenced by various factors, including the level of inflammation, the presence of other musculoskeletal issues, and individual variations in pain perception. Your experience of pain that does not alleviate with activity is significant and should be discussed with your healthcare provider.
3) Am I definitely suffering from Ankylosing Spondylitis?
Based on the information you provided, including your HLA-B27 positivity, MRI findings of bilateral sacroiliitis, and elevated inflammatory markers (CRP and ESR), it is reasonable to conclude that you have AS. However, the diagnosis of AS is not solely based on imaging or laboratory findings; it also considers clinical symptoms and the overall pattern of disease. Since you have not experienced morning stiffness and your pain does not improve with activity, it is essential to have an open dialogue with your rheumatologist. They may consider further evaluations or alternative diagnoses if your symptoms do not align with typical AS presentations.

In conclusion, while morning stiffness and pain relief with activity are common features of AS, they are not absolute indicators of the disease. Your unique symptom profile is important for your healthcare provider to understand in order to tailor your treatment effectively. Regular follow-ups and open communication with your rheumatologist will be key in managing your condition and addressing any concerns you may have.

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