Fundic Gland Polyps: What You Need to Know After a Gastroscopy - Gastroenterology and Hepatology

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Gastric fundic gland polyps?


Hello, Doctor.
I had an upper gastrointestinal endoscopy at a large hospital and discovered polyps.
Two weeks later, during a follow-up appointment, the doctor said the biopsy results indicated fundic gland polyps in the stomach and that there was no need to worry, as I could be monitored once every one to two years.
However, the doctor who performed the endoscopy and the one I consulted were different, so I asked the doctor how many polyps there were.
The doctor looked at the report and mentioned there were many, which made me quite anxious.

Could you please clarify if the report stating "Few Is polyps (2-3 mm) at body" means there are many polyps? Additionally, I am nearly 30 years old and have not used proton pump inhibitors (PPIs) long-term.
Should I be concerned about familial adenomatous polyposis due to the fundic gland polyps, and should I consider having a colonoscopy?
Here is the report:
Upper gastrointestinal endoscopy examination
Epigastralgia
Endoscope: GIF-H260-No844
Pre-medication: 10% Xylocaine local spray
Esophagus: Loosening of esophagocardiac junction, gastroesophageal flap valve Hill grade II.
Stomach: Mild mucosal hyperemia at antrum and body.
Few Is polyps (2-3 mm) at body, biopsy x2.
Duodenum: Negative to second portion of duodenum.
Ampulla not observed.
Endoscopic diagnosis: Loosening of esophagocardiac junction, Hill grade II.
Gastritis, Superficial Polyp, Stomach s/p biopsy
Biopsy: Biopsies were taken from stomach.
Please check Helicobacter pylori.
Advice: Procedure-related complication: nil.
GI OPD follow-up.
Pathology report content:
The specimen submitted consists of two tissue fragments, measuring up to 0.3 x 0.3 x 0.2 cm in size, fixed in formalin.
Grossly, they are gray and soft.
All for section.
Microscopically, it shows a picture of fundic gland polyp of stomach composed of attenuated foveolar gland and proliferation of parietal and chief cells with focal dilated glands in lamina propria.
No bacillus is seen in the superficial gastric pits by H&E stain.

Zhuang S, 20~29 year old female. Ask Date: 2023/03/31

Dr. Hu Guozheng reply Gastroenterology and Hepatology


Hello, please trust your examination and your attending physician.
If you have concerns about family history, it is advisable to schedule a follow-up appointment for the doctor to evaluate.
Thank you.

Reply Date: 2023/03/31

More Info


Understanding fundic gland polyps (FGPs) is essential, especially after undergoing a gastroscopy. Your recent findings indicate that you have a few small polyps (2-3 mm) in the body of your stomach, which were confirmed as fundic gland polyps through biopsy. These polyps are generally considered benign and are not associated with a significant risk of cancer, especially when they are small and without dysplasia.


Clarifying Your Concerns
1. Number of Polyps: The term "few" in medical terminology typically refers to a small number, often interpreted as 2-3. Therefore, having a few polyps (2-3 mm) does not imply a large number of polyps. It is understandable that the discrepancy between the endoscopist's and the consulting physician's descriptions may have caused some anxiety. However, based on your report, the presence of a few small fundic gland polyps is not uncommon and is usually not a cause for concern.

2. Age and Family History: At nearly 30 years old, the likelihood of developing familial adenomatous polyposis (FAP) or other hereditary syndromes that increase the risk of polyps is relatively low, especially if you do not have a family history of such conditions. Fundic gland polyps are often associated with chronic use of proton pump inhibitors (PPIs), but since you mentioned you do not have a long-term history of PPI use, this further reduces your risk profile.
3. Follow-Up and Surveillance: Your physician's recommendation for follow-up gastroscopies every one to two years is standard practice for monitoring fundic gland polyps. This is to ensure that there are no changes in the size or number of the polyps and to monitor for any potential development of dysplasia, although this is rare with fundic gland polyps.

4. Consideration for Colonoscopy: As for whether you should consider a colonoscopy, it is typically recommended based on personal or family history of colorectal cancer or polyps, or if you have gastrointestinal symptoms that warrant further investigation. Since your current findings are limited to the stomach and you have no significant risk factors, a colonoscopy may not be immediately necessary. However, it is always best to discuss this with your healthcare provider, who can assess your individual risk factors and symptoms.


Additional Information on Fundic Gland Polyps
Fundic gland polyps are generally benign lesions that arise from the gastric mucosa. They are often associated with chronic gastritis or the use of PPIs but are not known to progress to cancer. The histological examination of your biopsy showed no signs of dysplasia or malignancy, which is reassuring.
In terms of lifestyle modifications, maintaining a healthy diet, avoiding excessive alcohol consumption, and managing stress can contribute positively to gastric health. If you experience any new symptoms such as persistent pain, changes in appetite, or gastrointestinal bleeding, it is crucial to seek medical attention promptly.


Conclusion
In summary, your findings of fundic gland polyps are not uncommon and are generally not a cause for concern, especially given your age and lack of significant risk factors. Regular follow-up as advised by your physician is important, and you should feel comfortable discussing any further concerns or questions with your healthcare provider. They can provide tailored advice based on your specific health history and current findings.

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