Medication Abortion: Timing and Dosage Concerns - Obstetrics and Gynecology

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Medication abortion


Hello, doctor.
My girlfriend underwent a medical abortion with the first dose (Mifepristone) at the obstetrics and gynecology department on April 3rd around 1:00 PM.
She took the second dose (Misoprostol) at home at 6:00 PM the same day, but later realized that she took the second dose earlier than recommended.
Should she continue to take the remaining doses based on the medication's effectiveness, or should she wait for a full 48 hours?

Kami, 30~39 year old female. Ask Date: 2023/04/04

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, the second dose should be taken 48 hours later.
You have taken it incorrectly.
Please wait 48 hours before taking the remaining medication, and then return to your original clinic for follow-up.
Wishing you good health.

Reply Date: 2023/04/04

More Info


Medication abortion, also known as medical abortion, typically involves the use of two medications: mifepristone (often referred to by its brand name, Mifeprex or RU-486) and misoprostol (often referred to by its brand name, Cytotec). The process is designed to terminate an early pregnancy and is generally considered safe and effective when followed according to medical guidelines.

In your case, it appears that your girlfriend took mifepristone (the first medication) on April 3rd around 1 PM and then took misoprostol (the second medication) at 6 PM the same day. The standard protocol for a medication abortion is to take mifepristone first, followed by misoprostol 24 to 48 hours later. However, taking misoprostol earlier than the recommended time frame can raise concerns about its effectiveness and the potential for side effects.

While some studies suggest that taking misoprostol sooner than 48 hours after mifepristone may still be effective, it is generally recommended to adhere to the 24 to 48-hour window to ensure optimal results. If misoprostol is taken too early, it may not work as intended, and there is a possibility that the abortion may not be complete, which could necessitate further medical intervention.

If your girlfriend has already taken the second dose of misoprostol, it is important to monitor her for any signs of complications, such as heavy bleeding, severe pain, or fever. These symptoms could indicate that she may need to seek medical attention. Additionally, it is advisable to follow up with her healthcare provider to confirm that the abortion process is proceeding as expected and to discuss any concerns regarding the timing of the medication.

In terms of dosage, the typical dosage for misoprostol in the context of a medication abortion is usually 800 micrograms (four 200 microgram tablets) taken buccally (between the gums and cheek) or vaginally. If your girlfriend has taken a different dosage or method, it is crucial to consult with her healthcare provider for guidance.

In summary, while taking misoprostol earlier than the recommended time frame may still yield a successful outcome, it is essential to follow up with a healthcare provider to ensure that the abortion is complete and to address any potential complications. It is also important to remember that every individual's situation is unique, and healthcare providers can offer the best advice tailored to her specific circumstances. If there are any uncertainties or concerns, seeking medical advice is always the best course of action.

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