Myocardial hypoxia
Hello Dr.
Wu,
On March 30, I underwent a stress and redistribution myocardial perfusion scan at the hospital, and on April 14, when I returned to review the report, the doctor only mentioned that there was moderate myocardial hypoxia and immediately asked if I wanted to undergo a cardiac catheterization.
I was taken aback and didn't know how to respond, only saying that I would discuss it with my family at home.
While researching the purpose of the stress and redistribution myocardial perfusion scan online, I realized that during my follow-up visit, the doctor did not appear to review any reports or images.
I would like to ask if you could help me interpret the results of my report, which I found on the National Health Insurance app.
The application number is as follows:
Result:
Specimen:
Work Number:
Result: Yang Tsung-Han - NUCLEAR MEDICINE STUDY: Thallium-201 EKG-gated myocardial perfusion imaging (MPI), dipyridamole & resting.
INDICATION: Evaluating the presence and severity of coronary artery disease (CAD).
RADIOPHARMACEUTICAL: Intravenous 2.5 mCi Tl-201
SCINTIGRAPHIC FINDINGS:
* Thallium-201 myocardial perfusion imaging with EKG-gated SPECT was performed after a standardized dipyridamole stress protocol (dipyridamole 0.56 mg/kg continuous IV push in 4 minutes and aminophylline 100 mg IV push for symptom relief) and at rest.
* The initial and 4-hour delayed images showed:
(1) Moderate reversible perfusion defects in the basal anterolateral wall, basal septal wall, and basal anterior wall of the left ventricle (LV); mild reversible perfusion defects in the inferolateral wall, apical anterior wall, middle to basal inferior wall, and apical to middle inferoseptal wall of the LV; mild fixed perfusion defect in the apex of the LV.
(2) Normal pulmonary radiotracer uptake (Lung/Heart ratio, stress/resting: 0.46/0.53).
* Gated SPECT (8 frames per cardiac cycle, estimated by QGS method):
- Post-stress left ventricular ejection fraction (LVEF) = 71%; resting LVEF = 66%.
- Post-stress LV end-diastolic volume (EDV) = 89 ml, end-systolic volume (ESV) = 26 ml; resting LV EDV = 81 ml, ESV = 28 ml.
- Regional wall motion: no significant abnormality in wall motion of the LV.
IMPRESSION:
(1) Moderate stress-induced ischemia in the basal anterolateral wall (LCx territory), basal septal wall, and basal anterior wall (LAD territory) of the LV.
(2) Mild stress-induced ischemia in the inferolateral wall (LCx territory), apical anterior wall (LAD territory), middle to basal inferior wall, and apical to middle inferoseptal wall (RCA territory) of the LV.
(3) Attenuation artifact or hibernating tissue with mild ischemia in the apex of the LV.
(4) Fair LV contractility.
Yang Tsung-Han - Could you please help me understand whether the report indicates severe myocardial hypoxia? Thank you.
Mr. Huang, 40~49 year old female. Ask Date: 2023/04/17
Dr. Wu Xueming reply Cardiology
The report indicates the presence of moderate myocardial ischemia.
If angina symptoms persist despite medication management, it is recommended to perform a cardiac catheterization.
Reply Date: 2023/04/17
More Info
Understanding moderate myocardial ischemia is crucial for assessing your cardiovascular health, especially given your recent myocardial perfusion imaging (MPI) results. Your report indicates the presence of moderate reversible perfusion defects in several areas of the left ventricle (LV), specifically in the basal anterolateral wall, basal septal wall, and basal anterior wall. Additionally, there are mild reversible defects in other regions, including the inferolateral wall and apical anterior wall, as well as a mild fixed defect in the apex of the LV.
Key Insights from Your Report
1. Reversible Perfusion Defects: The term "reversible perfusion defects" suggests that during stress (induced by dipyridamole), certain areas of your heart muscle did not receive adequate blood flow, which is a sign of ischemia. The fact that these defects are reversible means that they may improve with rest or appropriate treatment, indicating that the ischemia is not permanent.
2. Severity of Ischemia: The report classifies the ischemia as moderate in the basal anterolateral, basal septal, and basal anterior walls. Moderate ischemia can indicate a significant reduction in blood flow that may lead to symptoms like chest pain or discomfort, especially during physical exertion.
3. Fixed Perfusion Defect: The presence of a mild fixed perfusion defect in the apex of the LV could suggest areas of myocardial scarring or hibernation, where the heart muscle is not functioning optimally due to previous ischemic events. This finding warrants further evaluation to determine the underlying cause and appropriate management.
4. Left Ventricular Function: Your left ventricular ejection fraction (LVEF) is reported as 71% post-stress and 66% at rest, which indicates that your heart's pumping ability is relatively preserved. However, the presence of ischemia, even with good contractility, suggests that there may be underlying coronary artery disease (CAD) that needs to be addressed.
5. Clinical Correlation: The report emphasizes the importance of correlating these imaging findings with your clinical symptoms and history. Given your symptoms of chest pain and the findings of moderate ischemia, your physician may recommend further diagnostic procedures, such as coronary angiography, to assess the severity and extent of any coronary artery blockages.
Next Steps
Given the findings of moderate ischemia, it is essential to have a thorough discussion with your cardiologist about the implications of these results. Here are some considerations:
- Further Testing: Your doctor may recommend additional tests, such as a coronary angiogram, to visualize the coronary arteries directly and assess for any significant blockages that may require intervention, such as angioplasty or stenting.
- Management Plan: Depending on the results of further testing, your management plan may include lifestyle modifications (diet, exercise, smoking cessation), medications (such as antiplatelet agents, statins, or beta-blockers), and possibly revascularization procedures if significant blockages are found.
- Monitoring Symptoms: Keep track of any changes in your symptoms, such as the frequency and intensity of chest pain or discomfort, and report these to your healthcare provider promptly.
- Family Discussion: Since you mentioned discussing the results with your family, it’s important to involve them in your healthcare decisions, as support can be crucial during this process.
In summary, while your report indicates moderate myocardial ischemia, the overall management and next steps will depend on a comprehensive evaluation by your healthcare team. It is essential to address these findings proactively to reduce the risk of future cardiac events and improve your overall heart health.
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