Norethisterone: Side Effects and Menstrual Cycle Management - Obstetrics and Gynecology

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Medication Consultation Shiton


Hello, I am about 12 days late for my period and the pregnancy test came back negative.
I have a trip scheduled for April 25 and hope to delay my period.
Therefore, I visited a gynecologist on April 21, and the doctor prescribed Norethisterone 5mg, to be taken three times a day, one tablet each time.
After taking one tablet on the night of April 21, I noticed bleeding symptoms around 1 AM.
I would like to know if this is a side effect of the medication or if my menstrual cycle just happened to start.
Should I continue taking this medication?

Niming, 30~39 year old female. Ask Date: 2023/04/22

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, take a few more pills and see how it goes.
If there is a lot of bleeding, it is likely that your period has started, so you should stop the medication.
Wishing you good health.

Reply Date: 2023/04/22

More Info


Norethisterone is a synthetic progestogen, commonly used in various gynecological treatments, including the management of menstrual disorders and to delay menstruation. When prescribed to delay a period, it is typically taken in doses of 5 mg three times a day for a short duration. In your case, you started taking Norethisterone on April 21, and you experienced bleeding shortly after taking the medication.
The bleeding you observed could be attributed to several factors. First, it is essential to understand that Norethisterone can cause side effects, including breakthrough bleeding, especially during the initial days of treatment. This is due to the hormonal changes the medication induces in your body. It is not uncommon for women to experience spotting or bleeding when they start taking hormonal medications, as the body adjusts to the new hormone levels.

Given that your menstrual cycle was already delayed by about 12 days before starting the medication, it is also possible that the bleeding you experienced was the onset of your menstrual period, coinciding with the timing of the medication. The timing of your bleeding suggests that your body may have been preparing to menstruate, and the introduction of Norethisterone could have triggered this process.

Regarding whether to continue taking the medication, it is crucial to follow your healthcare provider's instructions. If your doctor prescribed Norethisterone specifically to delay your period for your upcoming trip, you should continue taking it as directed unless you experience severe side effects or have concerns about the bleeding. If the bleeding becomes heavy or is accompanied by severe pain, it would be advisable to contact your healthcare provider for further guidance.

In terms of side effects, Norethisterone can cause various reactions, including:
1. Breakthrough Bleeding: As mentioned, this is common and may occur during the first few days of treatment.

2. Nausea: Some women may experience gastrointestinal discomfort.

3. Headaches: Hormonal changes can lead to headaches or migraines in some individuals.

4. Mood Changes: Hormonal medications can affect mood and emotional well-being.

5. Breast Tenderness: Some women report breast discomfort while taking progestogens.

It is essential to monitor your symptoms and communicate with your healthcare provider about any concerns. If you experience any severe side effects, such as chest pain, shortness of breath, or severe headaches, seek medical attention immediately.

In summary, the bleeding you experienced could be a side effect of Norethisterone or the onset of your menstrual cycle. Continue taking the medication as prescribed, and consult your healthcare provider if you have any concerns or if the bleeding persists or worsens. Your healthcare provider can provide personalized advice based on your medical history and current situation.

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