Long-Term Side Effects of Antidepressants: A Focus on Neurological Issues - Psychiatry

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Long-term use of Anliflu (5 mg/day for over 10 years, with the last 2-3 years at this dosage) may lead to symptoms such as ataxia, weakness in the hands, poor wrist control, difficulty touching the back of the head, hand weakness after taking hot showers, difficulty writing, dizziness, instability while walking, and swaying side to side when picking up items from the ground while sitting.
You are currently seeing a neurologist.

asdsa, 30~39 year old female. Ask Date: 2023/04/25

Dr. Qiu Junda reply Psychiatry


Hello.
I'm not sure what the causes and symptoms are for your visit to the neurology department.
It can be difficult to determine whether they are side effects of medication or symptoms of the underlying condition.
However, since you are visiting the neurology department, you can discuss and inquire about this with your physician during your follow-up appointment.

Reply Date: 2023/04/25

More Info


Long-term use of antidepressants, particularly SSRIs (Selective Serotonin Reuptake Inhibitors) like Anliflu (which is likely a brand name for a specific SSRI), can raise concerns about potential neurological side effects. While these medications are effective for treating depression and anxiety, their long-term impact on neurological function is an area of ongoing research and debate.

Firstly, it is important to understand that SSRIs primarily work by increasing serotonin levels in the brain, which can help improve mood and cognitive function. However, some patients report experiencing side effects that may affect their motor skills and cognitive abilities. The symptoms you describe, such as ataxia (loss of control of body movements), weakness in the hands, difficulty with fine motor skills (like writing), dizziness, and instability while walking, could be concerning and warrant further investigation.

One potential explanation for these symptoms could be related to the side effects of the medication itself. While SSRIs are generally well-tolerated, they can cause side effects such as dizziness, fatigue, and coordination issues in some individuals. These side effects may be exacerbated by other factors, such as age, the presence of other medical conditions, or the use of additional medications that may interact with the SSRI.

Another consideration is the possibility of serotonin syndrome, a rare but serious condition that can occur with excessive serotonin levels. Symptoms can include confusion, rapid heart rate, and muscle rigidity, but it typically occurs with higher doses or in combination with other serotonergic drugs. If you have been on a stable dose for an extended period, this is less likely to be the cause, but it is still worth discussing with your healthcare provider.

Additionally, the symptoms you are experiencing could also be indicative of other underlying neurological conditions. It is good to hear that you are consulting with a neurologist, as they can perform appropriate tests to rule out conditions such as peripheral neuropathy, multiple sclerosis, or other neurological disorders that could explain your symptoms.

In terms of long-term use of SSRIs, research has shown that while these medications can be effective for managing depression, there is a need for regular monitoring of side effects, especially with prolonged use. Some studies suggest that long-term use may lead to changes in brain chemistry or structure, but definitive conclusions are still lacking. It is essential to have open communication with your prescribing physician about any new or worsening symptoms you experience while on medication.

If you are concerned about the side effects of Anliflu or any other medication, it may be beneficial to discuss the possibility of adjusting your dosage or exploring alternative treatments. There are various classes of antidepressants and other therapeutic options available that may suit your needs without causing the side effects you are experiencing.

In summary, while long-term use of SSRIs can be beneficial for managing depression, it is crucial to monitor for any adverse effects, particularly neurological symptoms. Consulting with both your psychiatrist and neurologist will provide a comprehensive approach to your treatment and help ensure that you receive the most appropriate care for your situation. Regular follow-ups and open discussions about your symptoms will be key in managing your health effectively.

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