Localized Pain After COVID Vaccine: Is It Normal? - Family Medicine

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Concerns Regarding Post-COVID-19 Vaccination Issues


Hello, I would like to ask about the soreness I have been experiencing at the injection site for the past two to three months after receiving the fourth dose of the next-generation vaccine in October 2022.
The soreness is localized and not affecting the entire arm.
Given that it has been quite some time since the vaccination, could this be related to the vaccine? I did not experience this issue with the first three doses (AstraZeneca, AstraZeneca, Moderna).
Thank you.

Mika, 30~39 year old female. Ask Date: 2023/04/30

Dr. Lin Zhebin reply Family Medicine


Hello: The "local injection site reactions" that occur after vaccination typically last for a few days to a few weeks.
If you have been experiencing symptoms for 2-3 months, it is advisable to visit a rehabilitation specialist to check for any potential tendon or ligament injuries.

Reply Date: 2023/04/30

More Info


Localized pain at the injection site after receiving a COVID-19 vaccine, such as the fourth dose you received, is a common occurrence. Typically, side effects from vaccines, including localized pain, redness, or swelling, are expected to resolve within a few days to a few weeks. However, experiencing persistent pain for two to three months after vaccination raises some questions.

Firstly, it's important to understand that localized pain can be a result of the body's immune response to the vaccine. Vaccines work by stimulating the immune system to recognize and fight off pathogens, and this process can lead to inflammation at the injection site. This inflammation is usually temporary and should subside relatively quickly. In your case, since the pain has persisted for several months, it may not solely be attributed to the vaccine itself.

There are several potential explanations for your ongoing localized pain:
1. Injection Site Reaction: While most injection site reactions resolve quickly, some individuals may experience prolonged discomfort. This can be due to the technique used during the injection, such as hitting a nerve or muscle, or simply an exaggerated immune response.

2. Muscle Strain or Injury: If you have been using your arm more than usual or have engaged in activities that strain the shoulder or arm muscles, this could lead to localized pain that mimics a vaccine reaction.

3. Tendinitis or Bursitis: Inflammation of the tendons (tendinitis) or the bursa (bursitis) around the shoulder joint can also cause localized pain. These conditions can be exacerbated by repetitive movements or strain.

4. Other Medical Conditions: If you have underlying conditions such as fibromyalgia or chronic pain syndromes, these could also contribute to prolonged pain after vaccination.

Given that you did not experience similar issues after your previous vaccinations (AZ, AZ, Moderna), it may be worth considering that this particular reaction could be unique to the fourth dose or the specific vaccine formulation you received.

If the pain is affecting your daily activities or quality of life, it is advisable to consult a healthcare professional. A thorough evaluation may include a physical examination and possibly imaging studies to rule out any underlying issues such as tendon injuries or other musculoskeletal problems.
In the meantime, you can consider some self-care measures to alleviate discomfort:
- Rest: Avoid activities that exacerbate the pain.

- Ice Therapy: Applying ice to the affected area can help reduce inflammation and numb the pain.

- Over-the-Counter Pain Relief: Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can help manage pain and inflammation.

- Gentle Stretching and Strengthening Exercises: Once the acute pain subsides, gentle exercises may help restore mobility and strength to the area.

In summary, while localized pain after vaccination is common, persistent pain lasting several months warrants further investigation. It is essential to consult with a healthcare provider to explore the underlying causes and receive appropriate treatment. Your health and comfort are paramount, and addressing this issue can help ensure you remain healthy and active.

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