Abnormal Bleeding: Treatment Options for LSIL and CIN1 - Obstetrics and Gynecology

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Abnormal bleeding concerns?


Hello doctor, I am the one who asked you about bleeding after the biopsy a few days ago.
Thank you for your previous response.
The biopsy report just came out last night, and I went for a consultation.
The report indicates LSIL; CIN1.
The doctor mentioned that I could undergo cryotherapy or cervical conization.
Could you please clarify if these treatments involve removing the affected tissue to prevent further deterioration, or is there still a possibility of ongoing infection after the procedures?

Nìmíng, 30~39 year old female. Ask Date: 2023/05/05

Dr. Huang Yuande reply Obstetrics and Gynecology


The primary goal is to prevent deterioration, but the possibility of future infection with the papillomavirus cannot be ruled out.

Reply Date: 2023/05/05

More Info


When dealing with abnormal cervical findings such as LSIL (Low-grade Squamous Intraepithelial Lesion) and CIN1 (Cervical Intraepithelial Neoplasia grade 1), it is essential to understand both the nature of these conditions and the treatment options available. LSIL and CIN1 are generally considered mild abnormalities that often resolve on their own, particularly in younger women. However, monitoring and potential treatment are necessary to prevent progression to more severe lesions.

The treatment options you mentioned—cryotherapy (freezing treatment) and cone biopsy (cervical conization)—are indeed aimed at removing or destroying the abnormal tissue to prevent any potential progression to higher-grade lesions or cervical cancer. Cryotherapy involves freezing the abnormal cells, which causes them to die and be expelled by the body, while cone biopsy involves surgically removing a cone-shaped section of the cervix containing the abnormal cells.

1. Purpose of Treatment: The primary goal of these treatments is to eliminate the abnormal cells and reduce the risk of progression to more severe dysplasia or cervical cancer. While these procedures are effective in treating the lesions, they do not eliminate the risk of HPV (Human Papillomavirus) infection, which is the underlying cause of most cervical abnormalities. Therefore, even after treatment, it is still possible to have persistent HPV infection, which could lead to new lesions in the future.

2. Follow-Up Care: After undergoing treatment for LSIL or CIN1, regular follow-up is crucial. This typically involves Pap smears and HPV testing at intervals recommended by your healthcare provider. The follow-up schedule may vary based on individual risk factors and the specifics of your treatment. It is essential to adhere to these follow-up appointments to monitor for any recurrence of abnormal cells.

3. Risk of Persistent Infection: As mentioned, while treatments like cryotherapy and cone biopsy effectively address the current lesions, they do not guarantee that HPV will not persist or that new lesions will not develop. HPV can remain dormant in the body, and it is important to maintain regular gynecological check-ups to monitor for any changes.

4. Potential for Resolution: Many women with LSIL or CIN1 will find that their conditions resolve without treatment, particularly if they are younger and have a healthy immune system. The body can often clear HPV infections naturally, leading to the resolution of cervical lesions. However, if there are concerns about the persistence of abnormal cells or if the lesions progress, more aggressive treatment may be warranted.

5. Patient Education: It is vital for patients to be educated about the nature of HPV and cervical dysplasia. Understanding that these conditions are often manageable and that many women experience similar issues can help alleviate anxiety. Discussing sexual health, safe practices, and the importance of vaccination against HPV can also be beneficial.

In conclusion, while treatments for LSIL and CIN1 are effective in removing abnormal cells and preventing progression, they do not eliminate the risk of HPV infection or the possibility of future lesions. Regular follow-up care is essential to monitor cervical health and address any new developments promptly. If you have further concerns or questions about your specific situation, it is advisable to discuss them with your healthcare provider, who can provide personalized guidance based on your medical history and current health status.

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