Are Some People Immune to Flu? Exploring the Mystery of Natural Resistance - Influenza

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Is there really a chosen one?


I have not been diagnosed yet, but I might be an asymptomatic carrier.
Recently, my boyfriend contracted the flu and even infected his colleagues and friends.
As his partner, I surprisingly have not been infected at all; I haven't even experienced a cough or runny nose.
I recall that in the past, I have rarely been infected, mostly only with gastrointestinal issues or when I caught a chill.
I am curious if there is something different about my body or if it is simply pure luck.

Yu, 20~29 year old female. Ask Date: 2023/05/09

Dr. Chen Mingong reply Influenza


Hello, Yu: Indeed, there are so-called "chosen ones." Generally speaking, after being infected with a virus, it is not guaranteed that symptoms will manifest 100% of the time; some viruses have an attack rate of only 80% or 90%.
Therefore, in such cases, there is still a 10% to 20% chance that individuals who are infected may remain asymptomatic.
Most of the time, this can be confirmed later through serological testing for antibodies, which can verify that these individuals have indeed been infected.
You might be one of those asymptomatic individuals who have been infected without showing any symptoms.

Reply Date: 2023/05/09

More Info


The phenomenon of some individuals seemingly being immune to the flu, even when exposed to infected individuals, is indeed intriguing and can be attributed to several factors. While it may seem like luck, there are biological and immunological explanations that can shed light on this mystery.

Firstly, it is essential to understand that not everyone who is exposed to the influenza virus will develop symptoms or become ill. This is due to a variety of factors, including individual immune responses, genetic predispositions, and the nature of the virus itself. Some people may carry a genetic makeup that provides them with a more robust immune response to certain pathogens, including the flu virus. For example, variations in genes related to immune function, such as those coding for human leukocyte antigens (HLA), can influence how effectively a person's immune system recognizes and responds to viral infections.

Moreover, the concept of "asymptomatic carriers" plays a significant role in understanding this phenomenon. Some individuals can be infected with the flu virus but do not exhibit any symptoms. This can occur because their immune system effectively controls the virus without leading to an overt illness. In fact, studies suggest that a significant percentage of people who contract the flu may remain asymptomatic, which means they can carry and potentially spread the virus without showing any signs of illness themselves.

Another factor to consider is the role of pre-existing immunity. If you have been exposed to similar strains of the flu virus in the past, your immune system may have developed memory cells that can quickly recognize and combat the virus upon re-exposure. This is particularly relevant in the context of seasonal flu, where the virus can mutate but often retains similarities to previous strains.

Additionally, lifestyle factors can also contribute to an individual's resistance to infections. A healthy diet, regular exercise, adequate sleep, and effective stress management can all bolster the immune system. People who maintain a healthy lifestyle may have a more resilient immune response, making them less susceptible to infections, including the flu.

Lastly, environmental factors and the timing of exposure can also play a role. For instance, if you were exposed to the virus at a time when your immune system was particularly strong or if the viral load was low, you might not become infected.
In conclusion, while it may seem like luck that you have not contracted the flu despite close contact with an infected partner, there are several biological and lifestyle factors at play. Your immune system's efficiency, genetic predispositions, previous exposures, and overall health can all contribute to your apparent resistance to the flu virus. It is essential to continue practicing good hygiene, such as handwashing and vaccination, to further protect yourself from potential infections.

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