Food and Supplement Interactions While on PEP Treatment - Internal Medicine

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When it comes to understanding food and supplement interactions while on PEP (Post-Exposure Prophylaxis) treatment, particularly with the medication Biktarvy, there are several important considerations to keep in mind.

1. Calcium and Dairy Products: You mentioned that you consume 400cc of milk daily. It is true that dairy products, which are high in calcium, can potentially interfere with the absorption of certain medications, including some antiretrovirals. However, Biktarvy (which contains bictegravir, emtricitabine, and tenofovir alafenamide) is generally not significantly affected by calcium. The absorption of Biktarvy is not notably impaired by dairy products, unlike some other medications that are more sensitive to calcium. Nevertheless, it is always a good practice to take medications with a full glass of water and to space out the consumption of calcium-rich foods and medications by a couple of hours when possible, just to ensure optimal absorption.

2. Topical Corticosteroids: Regarding your question about using "倍宜乳膏" (Clobetasol Propionate), this is a potent topical corticosteroid used to treat inflammatory skin conditions. Generally, using topical corticosteroids while on PEP is considered safe, as they do not have systemic interactions with antiretroviral medications. However, it is important to use such medications as directed by your healthcare provider, especially considering the potency of Clobetasol. If you have concerns about skin reactions or the condition of your skin, it is advisable to consult with your dermatologist or healthcare provider for personalized advice.

3. Post-PEP Considerations: After completing a full 30 days of PEP treatment, it is crucial to understand that while the risk of HIV transmission is significantly reduced, the interactions between medications and food do not completely disappear. You may be able to resume a more typical diet, including alcohol and caffeine, but moderation is key. Alcohol can affect liver function, which is important to consider when taking any medication, including those for HIV. Additionally, while you may not need to be as vigilant about food interactions after completing PEP, it is still wise to maintain a balanced diet and be mindful of any supplements you take, as some can still interact with medications.

In summary, while on PEP treatment with Biktarvy, consuming dairy in moderation is generally acceptable, using topical corticosteroids like Clobetasol is safe, and after completing PEP, you can gradually return to a normal diet but should still be cautious with alcohol and supplements. Always consult your healthcare provider for personalized advice tailored to your specific health needs and circumstances. They can provide the most accurate guidance based on your overall health, any other medications you may be taking, and your individual dietary habits.