the Link Between Coughing and Pulmonary Hypertension in Women - Cardiology

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Continuing from #197363, I would like to inquire about cough and pulmonary hypertension?


Hello, Doctor.
I am a 37-year-old female with no history of hypertension, diabetes, or hyperlipidemia.
I do not smoke or drink alcohol, am slightly underweight, exercise occasionally, and do not stay up late.
I have mild gastroesophageal reflux and have experienced chest tightness for the past two weeks.

The electrocardiogram report indicates myocardial ischemia with the following diagnostic and examination purposes: 78650-1 CHEST PAIN, 78609 DYSPNEA, 413.9 OTHER AND UNSPECIFIED ANGINA PECTORIS.

M-Mode, TWO DIMENSIONAL & DOPPLER STUDIES show:
- RVD: 1.3 (0.7-2.3)
- Mitral valve structure: REGURG VELOCITY STENOSIS
- LVDD: 4.4 (3.5-5.5)
- EF slope: (80-370 mm/s)
- Grading: m/sec Gradient mmHg
- LVSD: 2.3 (1.9-3.9)
- Excursion: (15-30 mm)
- Max/Mean Peak/Mean IVS: 0.7 (0.5-1.2)
- Ao: 2.2 (1.7-4.0)
- MV: /3 / /
- LVPW: 0.7 (0.5-1.1)
- LA: 2.8 (2.0-4.0)
- AV: /3 / /
- Pericardial: □ TV /4 / / effusion (-)
- PV: /4 / /
Regional Wall Motion: Mild hypokinesia of IVS & LV apex
Mitral Valve: MVP, MR
Aortic Valve: ■
Tricuspid Valve: □ TVP TR+, RVSP = 31.1 mmHg
Pulmonary Valve: □ □
Left Ventricular Function: Dias.
vol Syst.
vol.
EF: 57% (50-70)
Interpretation:
1.
Normal chamber size.
2.
MVP with trivial MR.
TVP with mild TR.
3.
Mild pulmonary hypertension (RVSP: 31.1 mmHg).
4.
Normal thickness of IVS and LV walls.
5.
Mild hypokinesia of IVS and LV apex but preserved LV systolic function (LVEF = 57%).
6.
LV diastolic dysfunction (pseudonormal mitral inflow velocity pattern).
Recently, I have experienced more frequent productive coughs, triggered by an itchy throat.
I currently do not have a confirmed diagnosis of COVID-19 and show no signs of a cold.
I would like to know if this could be related to the pulmonary hypertension indicated in the report.
What further examinations would you recommend? Thank you.

Xiao Qi, 30~39 year old female. Ask Date: 2023/06/15

Dr. He Dongjin reply Cardiology


Hello, frequent coughing with phlegm and an itchy throat that makes you want to cough are likely related to respiratory issues and are not associated with pulmonary hypertension.
Don't overthink it.
Changhua Hospital cares about you.

Reply Date: 2023/06/15

More Info


Coughing and pulmonary hypertension (PH) can indeed be interconnected, but the relationship is often complex and multifactorial. In your case, as a 37-year-old woman with mild pulmonary hypertension indicated by a right ventricular systolic pressure (RVSP) of 31.1 mmHg, it’s essential to understand the potential implications of your symptoms and the underlying conditions.

Firstly, pulmonary hypertension is characterized by elevated blood pressure in the pulmonary arteries, which can lead to various symptoms, including shortness of breath, fatigue, and chest discomfort. However, coughing, particularly when it is productive (producing phlegm), is not a typical symptom directly associated with pulmonary hypertension. Instead, it is more commonly linked to respiratory conditions such as bronchitis, asthma, or infections.

In your case, the recent onset of frequent coughing with phlegm and throat irritation could suggest an upper respiratory issue or bronchial irritation rather than a direct consequence of pulmonary hypertension. Given that you have a history of gastroesophageal reflux disease (GERD), it is also possible that acid reflux could be contributing to your throat irritation and subsequent cough. GERD can lead to chronic cough due to aspiration or irritation of the airways.

Your echocardiogram results indicate mild pulmonary hypertension, which is not uncommon and may not require immediate treatment if you are asymptomatic. However, it is crucial to monitor this condition regularly, especially if you start experiencing more pronounced symptoms like increased shortness of breath or chest pain.

Regarding further investigations, it would be prudent to consider the following:
1. Pulmonary Function Tests (PFTs): These tests can help assess your lung capacity and function, providing insights into whether there are any obstructive or restrictive lung diseases contributing to your cough.

2. Chest X-ray or CT Scan: If not already done, imaging studies can help rule out any structural lung issues, such as infections, nodules, or emphysema, which could explain your cough.

3. Bronchoscopy: If your cough persists and is unresponsive to treatment, a bronchoscopy may be warranted to directly visualize the airways and obtain samples for further analysis.

4. Gastroenterology Consultation: Given your history of GERD, consulting a gastroenterologist may be beneficial to evaluate the management of your reflux symptoms, which could be contributing to your respiratory issues.

5. Allergy Testing: If you have a history of allergies or asthma, testing may help identify any triggers that could be exacerbating your symptoms.

In summary, while there may be a connection between your cough and pulmonary hypertension, it is more likely that your cough is related to other respiratory or gastrointestinal issues. Regular follow-up with your healthcare provider is essential to monitor your pulmonary hypertension and address any new or worsening symptoms. If your cough persists or worsens, further evaluation will be necessary to determine the underlying cause and appropriate management.

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