Managing Irregular Periods: Hormonal Imbalance and Treatment Options - Obstetrics and Gynecology

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I must take medication for my menstrual cycle to occur?


Hello, doctor...
I have no sexual experience.
My menstrual cycle has been very irregular, and it often does not come on its own for a long time.
I have had blood tests done, which indicated that I have elevated male hormones and low female hormones.
I took medication (Diane 35 or Androcur) for about six months, and during that time, my period would come regularly as long as I took the medication.
However, once I stopped taking it, my period did not return.
What should I do? Is it safe to take that kind of medication long-term? Are there any further tests I can undergo? Will it be more difficult for me to conceive in the future? Thank you.

pon, 20~29 year old female. Ask Date: 2003/12/25

Dr. Mao Yikun reply Obstetrics and Gynecology


Hello: From your description, it seems that you may have reduced ovarian function leading to anovulation.
Of course, you can further investigate the underlying causes.
Diane 35 is a menstrual regulation medication that currently has no significant side effects, so it can be taken.
If you wish to conceive in the future, with the advancements in ovulation medications today, inducing ovulation should not be difficult, so there is no need to worry.

Reply Date: 2003/12/25

More Info


Managing irregular periods can be a complex issue, particularly when hormonal imbalances are involved. Based on your description, it appears that you have been diagnosed with elevated levels of male hormones (androgens) and lower levels of female hormones (estrogens). This hormonal imbalance can lead to irregular menstrual cycles, and it is not uncommon for women in similar situations to experience difficulties in regulating their periods.

The medication you mentioned, Diane 35 (which contains cyproterone acetate and ethinylestradiol), is often prescribed to manage conditions like polycystic ovary syndrome (PCOS) or other hormonal imbalances. This medication works by suppressing the effects of androgens and providing estrogen, which can help regulate your menstrual cycle. However, as you noted, once you stop taking the medication, your periods may not return to normal. This is a common concern among women using hormonal contraceptives or treatments for hormonal imbalances.

Long-term use of hormonal medications like Diane 35 can be safe for many women, but it is essential to discuss the risks and benefits with your healthcare provider. Potential side effects can include weight gain, mood changes, and an increased risk of blood clots, especially in women who smoke or have other risk factors. Your doctor can help you weigh these risks against the benefits of regulating your menstrual cycle and managing symptoms related to hormonal imbalance.

If you are considering further evaluation, there are several tests that can provide more insight into your hormonal status and reproductive health. These may include:
1. Hormonal Profile: A comprehensive blood test to measure levels of various hormones, including estrogen, progesterone, testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH). This can help identify specific imbalances.

2. Ultrasound: A pelvic ultrasound can help visualize the ovaries and uterus, checking for conditions like polycystic ovaries or uterine abnormalities.

3. Thyroid Function Tests: Since thyroid disorders can also affect menstrual cycles, checking your thyroid hormone levels may be beneficial.

4. Glucose Tolerance Test: This is particularly relevant if you have symptoms of insulin resistance, which is common in women with PCOS.

Regarding your concern about future pregnancies, hormonal imbalances can affect fertility, but many women with irregular periods can still conceive. Treatment options to restore hormonal balance can improve your chances of pregnancy. If you are planning to conceive in the future, it may be helpful to work with a reproductive endocrinologist or a fertility specialist who can provide tailored advice and treatment options.

In summary, managing irregular periods due to hormonal imbalances involves a combination of lifestyle changes, potential medication, and ongoing monitoring of your hormonal health. It is crucial to maintain open communication with your healthcare provider to find the most appropriate treatment plan for your specific situation. If you have further questions or concerns, do not hesitate to reach out to your doctor for personalized advice and support.

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