Post-COVID Symptoms: Yellow Nasal Discharge and Vasculitis Concerns - Otolaryngology

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Post-nasal drip and vasculitis?


Hello, doctor.
About two weeks ago, I tested positive for COVID-19, and approximately four days ago, I suddenly developed numerous petechiae on my calves.
I went to the hospital's dermatology department for an examination, where they performed blood tests and a urinalysis.
All values were normal, including CBC, CRP, ESR, creatinine, AST, ALT, and immune-related tests such as ANA, C3, C4, and anti-dsDNA.
The urine test was also normal, so the doctor prescribed steroids to be taken once in the morning and once at night, and I was advised to return for a follow-up.
However, since my diagnosis, I have noticed that for the past week, I have been experiencing yellow nasal discharge that drains into my throat, although I do not have significant nasal congestion and do not need to blow my nose.
Today, I felt a slight aching sensation in my left eye, and I came across reports indicating that one type of vasculitis classified as ANCA can present with sinusitis symptoms, which makes me quite concerned.
I visited an ENT clinic today, and the doctor used an endoscope to examine my nasal passages and nasopharynx, stating that everything appeared normal, although there was some thickened mucus.
I would like to ask if this indicates that my sinuses are normal.
Why am I still experiencing yellow nasal discharge or a sensation of eye strain? Should I undergo blood tests for ANCA-associated vasculitis? Other doctors have mentioned that symptoms of this type of vasculitis tend to be more severe, but since my blood and urine tests are normal, it should not be the case.

Guang, 40~49 year old female. Ask Date: 2023/06/29

Dr. Zheng Jueyi reply Otolaryngology


Hello, if all immune-related blood tests are normal and there is no history of rheumatologic or autoimmune diseases, along with no significant abnormalities found during the endoscopic examination, the likelihood of developing vasculitis is very low.
It may be advisable to either observe the situation or start treatment with clinic-prescribed medications.
If there is no significant improvement, a follow-up appointment for further evaluation and treatment will be necessary.

Reply Date: 2023/06/29

More Info


Post-COVID symptoms can be quite complex and varied, and your experience with yellow nasal discharge and concerns about vasculitis is not uncommon among those who have recovered from COVID-19. Let's break down your symptoms and the potential underlying causes.

Firstly, the presence of yellow nasal discharge, especially if it is accompanied by post-nasal drip (where mucus flows down the back of the throat), can indicate several conditions. In many cases, yellow nasal discharge suggests that there may be an infection, such as sinusitis (inflammation of the sinuses) or a secondary bacterial infection following a viral illness like COVID-19. However, it can also be a result of allergic rhinitis or other non-infectious causes, particularly if you have a history of allergies.

The fact that you have experienced this yellow discharge after a recent COVID-19 infection raises the possibility of post-viral syndromes. Some patients report ongoing respiratory symptoms, including increased mucus production, nasal congestion, and sinus pressure, even after the acute phase of the infection has resolved. This could be due to lingering inflammation in the nasal passages and sinuses.

Regarding your concern about ANCA-associated vasculitis, it is important to note that while ANCA vasculitis can present with respiratory symptoms, it typically comes with more severe systemic symptoms, such as significant fatigue, fever, and other organ involvement. Your normal blood tests, including CBC, CRP, and specific autoimmune markers (ANA, C3, C4, A-DSDNA), suggest that there is no active autoimmune process at play. The fact that your ENT specialist found no significant abnormalities during the nasal endoscopy is also reassuring. It indicates that there is likely no structural issue in your nasal passages or sinuses.

The yellow nasal discharge you are experiencing could be due to several factors, including:
1. Post-viral Rhinosinusitis: After a viral infection, the mucosal lining of the nasal passages can remain inflamed, leading to increased mucus production and yellow discharge.

2. Allergic Rhinitis: If you have a history of allergies, exposure to allergens can exacerbate your symptoms, leading to increased mucus production and post-nasal drip.

3. Environmental Factors: Changes in weather, humidity, or exposure to irritants can also contribute to nasal symptoms.

4. Sinusitis: While your endoscopy was normal, it is still possible to have mild sinusitis that does not show significant findings on examination but can cause symptoms like yellow discharge.

As for the left eye discomfort, this could be related to sinus pressure or irritation of the surrounding tissues, which is not uncommon when dealing with nasal and sinus issues.

In terms of further testing for ANCA vasculitis, given your normal lab results and the absence of significant symptoms, it may not be necessary at this time. However, if you develop new symptoms or if your current symptoms worsen, it would be prudent to follow up with your healthcare provider for further evaluation.

In conclusion, your symptoms are likely related to post-viral changes following COVID-19, possibly exacerbated by allergies or environmental factors. It is essential to monitor your symptoms and maintain communication with your healthcare provider. If your symptoms persist or worsen, further evaluation may be warranted. In the meantime, consider using saline nasal sprays or rinses to help clear mucus and keep your nasal passages moist, and discuss with your doctor the potential use of antihistamines if allergies are suspected.

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