Breast Calcifications: Should You Take Medication? - Breast and Thyroid

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Breast calcifications do not typically require medication?


Hello Doctor, I previously had a mammogram and ultrasound, and it was later mentioned that there were calcifications.
I was advised to undergo a localization biopsy (the kind done under general anesthesia) for further examination, which I completed.
During my follow-up appointment, I was informed that the results were benign, but there is still a possibility of it becoming malignant.
Consequently, I was prescribed Novaldex (Tamoxifen) to take once a day for three years.
I was also told that after starting the medication, I need to have a gynecological check-up because there is a risk of endometrial hyperplasia (which I found out could lead to potential uterine pathology).
I have been menopausal for about a year now.
I am hesitant about whether I should take the medication or not.
If I take it, is there a chance of developing cancer elsewhere? Thank you, Doctor, for taking the time to respond and explain.

Ms. C, 50~59 year old female. Ask Date: 2023/07/09

Dr. Yuan Tianmin reply Breast and Thyroid


Since there are no reports available, I cannot provide a precise answer regarding whether you should take medication.
However, I suggest asking your attending physician if it is possible to manage without medication.

Reply Date: 2023/07/09

More Info


Understanding breast calcifications and the subsequent recommendations for medication can be quite complex, especially when navigating the potential risks and benefits involved. In your case, it seems that you underwent imaging studies that revealed calcifications in your breast, which led to a recommendation for a localization biopsy under general anesthesia. Fortunately, the results indicated that the calcifications were benign, but your healthcare provider has expressed concerns about the potential for these calcifications to become malignant in the future.

Breast calcifications are small deposits of calcium that can form in the breast tissue. They are often detected during mammograms and can be classified into two categories: macrocalcifications and microcalcifications. Macrocalcifications are usually benign and often associated with aging, while microcalcifications can sometimes indicate the presence of breast cancer, particularly if they are clustered or have irregular shapes. The fact that your biopsy results were benign is reassuring, but it is understandable that your doctor is being cautious about the potential for future changes.

The medication you have been prescribed, likely a selective estrogen receptor modulator (SERM) such as tamoxifen (often referred to by its brand name, Novaldex), is commonly used in patients with a history of breast abnormalities to reduce the risk of developing breast cancer. This medication works by blocking estrogen receptors in breast tissue, which can help prevent the growth of estrogen-dependent tumors. However, it is important to note that while tamoxifen can reduce the risk of breast cancer, it is not without its side effects and potential risks.

One of the concerns associated with long-term use of tamoxifen is the risk of endometrial hyperplasia, which is an overgrowth of the cells lining the uterus. This condition can increase the risk of endometrial cancer, especially in postmenopausal women. Given that you have been menopausal for about a year, your healthcare provider's recommendation for regular gynecological check-ups is prudent. Monitoring the health of your uterus through pelvic exams and possibly ultrasound can help detect any changes early.

When considering whether to take the medication, it is essential to weigh the benefits against the risks. The decision should be made in collaboration with your healthcare provider, who can help you understand your individual risk factors for breast cancer, the potential benefits of taking the medication, and the implications of not taking it. Additionally, discussing your concerns about the possibility of developing other cancers as a result of taking the medication is crucial.
It is also worth noting that lifestyle factors can play a significant role in breast health. Maintaining a healthy weight, engaging in regular physical activity, and following a balanced diet rich in fruits, vegetables, and whole grains can contribute positively to your overall health and potentially reduce cancer risk.

In summary, the decision to take medication after a diagnosis of benign breast calcifications should be made carefully, considering both the potential benefits of reducing breast cancer risk and the risks associated with the medication itself. Regular follow-up with your healthcare provider is essential to monitor your health and make any necessary adjustments to your treatment plan. If you have further questions or concerns, do not hesitate to reach out to your healthcare team for personalized advice and support.

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