Glycated Hemoglobin Levels in Children: Is It Prediabetes? - Pediatrics

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Glycated hemoglobin


Hello Doctor: For a 15-year-old child, the fasting blood glucose level is 87 mg/dL, and the hemoglobin A1c is 5.7% (with a reference range of 4-6%).
Does this indicate prediabetes?

Xiao Wen, 40~49 year old female. Ask Date: 2023/07/18

Dr. Xiao Kaiwen reply Pediatrics


A hemoglobin A1c level between 5.7% and 6.4% is classified as prediabetes, even if fasting blood glucose levels are normal.
It is recommended to seek evaluation and treatment from a pediatric endocrinology department at a major hospital.

Reply Date: 2023/07/18

More Info


When evaluating glycated hemoglobin (HbA1c) levels in children, it is essential to understand the implications of the results in the context of diabetes risk. In your case, the 15-year-old child has an HbA1c level of 5.7%, which falls within the range that indicates prediabetes. According to the American Diabetes Association (ADA), an HbA1c level of 5.7% to 6.4% is classified as prediabetes, while levels of 6.5% or higher are indicative of diabetes.

The fasting blood glucose level of 87 mg/dL is within the normal range, as normal fasting blood glucose levels are typically below 100 mg/dL. However, it is crucial to note that prediabetes can occur even when fasting blood glucose levels are normal. This is because HbA1c provides an average of blood glucose levels over the past two to three months, reflecting the child's overall glucose control rather than a single point in time.

Prediabetes is a significant health concern, as it indicates an increased risk of developing type 2 diabetes in the future. It is often associated with insulin resistance, where the body's cells do not respond effectively to insulin, leading to elevated blood glucose levels over time. Factors contributing to insulin resistance include obesity, physical inactivity, and a family history of diabetes.

In managing prediabetes, lifestyle modifications are critical. Here are some recommendations:
1. Dietary Changes: Encourage a balanced diet rich in whole grains, fruits, vegetables, lean proteins, and healthy fats. Reducing the intake of sugary beverages and high-calorie snacks can help maintain a healthy weight and improve insulin sensitivity.

2. Physical Activity: Regular physical activity is vital for maintaining a healthy weight and improving insulin sensitivity. Aim for at least 150 minutes of moderate-intensity exercise per week, such as brisk walking, cycling, or swimming.

3. Weight Management: If the child is overweight, even a modest weight loss of 5-10% can significantly reduce the risk of developing type 2 diabetes.

4. Regular Monitoring: It is essential to monitor blood glucose levels and HbA1c periodically to assess the effectiveness of lifestyle changes and determine if further intervention is necessary.

5. Medical Consultation: Consulting with a pediatric endocrinologist or a healthcare provider specializing in diabetes management can provide tailored advice and support. They may recommend further testing or monitoring based on the child's individual risk factors.

In conclusion, while an HbA1c level of 5.7% does indicate prediabetes, it is not a definitive diagnosis of diabetes. It serves as a warning sign that lifestyle changes are necessary to prevent the progression to type 2 diabetes. By implementing healthy habits and working closely with healthcare professionals, the child can significantly reduce their risk and promote long-term health.

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