Pregnancy Concerns: Is Povidone-Iodine Safe for Expecting Mothers? - Obstetrics and Gynecology

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Hello, doctor.
I am currently 27 weeks pregnant and have recently caught a cold with a very sore throat.
Before my pregnancy, I had a habit of using Povidone-iodine (0.45% w/v) for colds, and I naturally used it this time as well.
However, after using it, I checked online and found that it is not recommended for pregnant women.
I would like to ask if using it two or three times will affect the fetus, or if I need to go to the hospital for any checks.

Jiang Xiaojie, 30~39 year old female. Ask Date: 2023/08/12

Dr. Chen Zhiyu reply Obstetrics and Gynecology


Contraindications: Individuals with thyroid disorders, those allergic to iodine products, pregnant women, breastfeeding mothers, and children under 6 years of age are advised to consult a physician in an outpatient setting.
Thank you.

Reply Date: 2023/08/12

More Info


When it comes to the safety of medications during pregnancy, it is crucial to understand the potential risks and benefits associated with their use. Povidone-iodine, commonly known as Betadine, is an antiseptic that is often used for disinfecting skin before surgery or for treating minor wounds. However, its use during pregnancy raises some concerns.

Povidone-iodine is classified as a Category C drug by the FDA, which means that animal reproduction studies have shown an adverse effect on the fetus, but there are no adequate and well-controlled studies in pregnant women. This classification indicates that while there may be some risks, the potential benefits of using the drug may outweigh those risks in certain situations.

In your case, using povidone-iodine as a throat spray for a sore throat during your 27th week of pregnancy is not recommended without consulting your healthcare provider. The primary concern with povidone-iodine is its iodine content, which can potentially affect thyroid function in both the mother and the developing fetus. Excessive iodine exposure during pregnancy can lead to thyroid dysfunction, which may have implications for fetal development.

If you have used povidone-iodine a few times, it is unlikely to cause significant harm, especially if you did not use it excessively. However, it is essential to monitor for any unusual symptoms or changes in your health. If you experience any adverse effects or if you have concerns about your baby's health, it is advisable to consult your obstetrician or healthcare provider. They may recommend additional monitoring or tests to ensure that everything is progressing normally.

In general, when dealing with any illness during pregnancy, it is best to consult with your healthcare provider before using any medication or treatment. They can provide guidance on safe alternatives that are more suitable for pregnant women. For sore throats, options such as saline gargles, warm teas with honey, or throat lozenges that are deemed safe during pregnancy may be recommended.

Additionally, it is important to maintain good overall health during pregnancy. This includes staying hydrated, eating a balanced diet, and getting adequate rest. If your sore throat persists or worsens, or if you develop other symptoms such as fever or difficulty swallowing, seek medical attention promptly.

In summary, while the occasional use of povidone-iodine may not pose a significant risk, it is always best to err on the side of caution and consult with your healthcare provider regarding any medications or treatments during pregnancy. They can provide personalized advice based on your specific health needs and circumstances.

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