Antibiotic Resistance in Eye Drops: What You Need to Know - Ophthalmology

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Antibiotic resistance issues with eye drops?


Hello, doctor.
My physician diagnosed me with eye inflammation (the doctor only mentioned inflammation but did not specify whether it is conjunctivitis or keratitis) and advised against using steroid-containing eye drops (as it could lead to acute glaucoma).
Instead, I was prescribed Tobramycin eye drops, which helped significantly.
I used them for about 3 to 4 weeks, and since I had minimal symptoms, I gradually stopped using them.
However, the condition has recurred, and now it seems that using the drops for an extended period is ineffective.
I suspect there is a high possibility of antibiotic resistance.
I regret not continuing the treatment.
My question is, Tobramycin seems to be a very potent eye drop; is there any eye drop with stronger antibacterial properties than this? I am really worried that there may be no medication left to treat my eyes.
Is it still possible to achieve a full recovery? Thank you in advance for your response.

Zhang, 30~39 year old female. Ask Date: 2023/08/16

Dr. Gao Pilin reply Ophthalmology


Hello: Colistin is an antibiotic eye drop commonly used to treat eye infections.
In your case, there may be a possibility of antibiotic resistance, which could result in the medication being less effective than expected.
Prolonged use of the same eye drop can lead to the body developing resistance, reducing the drug's efficacy.
If your eyes have developed resistance to colistin, your physician may need to reassess your condition and recommend alternative treatment options.
There are various types of eye drops available on the market for treating different types of eye infections and inflammation.
If colistin is no longer effectively treating your condition, your physician may consider other medications or treatment methods.
Please see an ophthalmologist for an examination as soon as possible.

Reply Date: 2023/08/16

More Info


Antibiotic resistance in eye drops is a significant concern, particularly for patients who have experienced recurrent eye infections or inflammation. In your case, it appears that you were prescribed a topical antibiotic, likely to treat an eye infection or inflammation, and after a period of improvement, you stopped using the medication, leading to a recurrence of symptoms. This situation raises important questions about the effectiveness of the antibiotic and the potential for developing resistance.

Firstly, it's essential to understand that antibiotics, including those used in eye drops, can lead to resistance if they are not used correctly. When you stop using an antibiotic prematurely, it may not eliminate all the bacteria, allowing the surviving bacteria to adapt and become resistant to that antibiotic. This is particularly concerning with topical antibiotics like the one you mentioned (likely to be a brand name for a fluoroquinolone or similar antibiotic), as they are often used for short durations to treat localized infections.

Regarding your question about whether there are stronger antibiotics than the one you were prescribed, it is important to note that the effectiveness of an antibiotic depends on the specific bacteria causing the infection. Some bacteria may be resistant to certain antibiotics, while others may be susceptible. Therefore, if you have developed resistance to the antibiotic you were using, your healthcare provider may need to perform a culture and sensitivity test to identify the specific bacteria and determine which antibiotics are still effective against it. This testing can guide your doctor in prescribing a more effective treatment.

As for your concern about whether your condition can be treated, the answer is yes, but it may require a different approach. If resistance is suspected, your doctor may prescribe a different class of antibiotic or a combination of medications to effectively treat the infection. In some cases, they may also consider non-antibiotic treatments, such as anti-inflammatory medications or corticosteroids (if appropriate), to manage inflammation and promote healing.

In addition to medication, there are several supportive measures you can take to help your eyes heal. These include:
1. Maintaining Good Hygiene: Wash your hands frequently and avoid touching your eyes to prevent introducing new bacteria.

2. Warm Compresses: Applying warm compresses to your eyes can help relieve discomfort and promote drainage if there is any blockage in the glands.

3. Artificial Tears: If you experience dryness or irritation, using preservative-free artificial tears can help keep your eyes lubricated.

4. Follow-Up Appointments: Regular follow-ups with your eye care provider are crucial to monitor your condition and adjust treatment as necessary.

5. Avoiding Contact Lenses: If you wear contact lenses, consider taking a break until your eyes have fully healed, as lenses can exacerbate irritation and increase the risk of infection.

6. Diet and Hydration: Staying hydrated and maintaining a balanced diet can support your immune system, which is essential for fighting infections.

In conclusion, while antibiotic resistance is a valid concern, there are still effective treatment options available. It is crucial to communicate openly with your healthcare provider about your symptoms and treatment history. They can guide you through the next steps, whether that involves changing your medication or exploring alternative treatments. Remember, early intervention and adherence to prescribed treatments are key to preventing recurrence and ensuring the best possible outcome for your eye health.

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