Low GPT and GOT Levels: Causes and Implications for Liver Health - Gastroenterology and Hepatology

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Understanding low levels of GPT (Glutamate Pyruvate Transaminase) and GOT (Glutamate Oxaloacetate Transaminase) is essential for assessing liver health. In your case, the observed values of GPT at 11 IU/L and 9 IU/L, along with a GOT level of 14 IU/L, indicate that both enzymes are below the normal reference ranges. Typically, normal ranges for GPT are around 14-40 IU/L and for GOT around 15-41 IU/L, though these can vary slightly depending on the laboratory.

Low levels of these liver enzymes can be perplexing, especially when they were previously within normal limits. It is important to note that low GPT and GOT levels are generally not considered clinically significant. In many cases, they do not indicate any underlying health issues. For instance, individuals who are physically fit, have a lean body mass, or follow a healthy diet may naturally exhibit lower enzyme levels. Additionally, certain genetic factors or variations in metabolism can also contribute to lower enzyme levels without any adverse health implications.

Regarding your specific situation, you mentioned that you have been taking enteric-coated aspirin (安心平腸溶微粒膠囊) at a dosage of 100 mg daily since April. While aspirin is primarily known for its anti-inflammatory and analgesic properties, it is not typically associated with causing significant reductions in liver enzyme levels. In fact, aspirin is often considered safe for the liver when used at recommended doses. However, it is crucial to monitor any medication's effects on your body, especially if you notice changes in your health metrics.

If the decrease in GPT and GOT levels continues or if you experience any symptoms such as fatigue, jaundice, or abdominal pain, it would be prudent to consult with a healthcare professional. They may recommend further testing to rule out any potential liver dysfunction or other underlying conditions. It is also essential to consider other factors that could contribute to low enzyme levels, such as nutritional deficiencies, hydration status, or even the timing of your blood tests relative to meals or medications.

In summary, while low GPT and GOT levels can raise questions, they are often not a cause for concern, especially in the absence of other symptoms or abnormal findings. Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and avoiding excessive alcohol consumption, will support overall liver health. If you have any ongoing concerns or if your enzyme levels continue to decline, seeking advice from a healthcare provider specializing in liver health would be the best course of action. They can provide personalized guidance based on your medical history and current health status.