Managing Epilepsy: Navigating Medication Side Effects and Emotional Health - Neurology

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Antiepileptic drugs


I had surgery on my head due to a car accident during high school.
I was fine for many years, but after 20 years, I developed post-traumatic epilepsy, which occurs occasionally when I am very tired.
Initially, I was only taking one medication, but after experiencing several seizures in close succession, my doctor prescribed an additional medication called Depakote.
However, every time I take this medication, it causes me to feel emotionally low, leads to intrusive thoughts, and disrupts my sleep, even to the point of having suicidal thoughts.
Once the medication wears off, I feel fine again.
Should I continue taking it?

Juzi, 40~49 year old female. Ask Date: 2023/09/03

Dr. Cai Zongzhang reply Neurology


Hello, regarding post-traumatic brain injury sequelae, seizures are quite common.
Physicians often choose to use antiepileptic drugs; however, there are various medications available.
It is advisable to discuss with your doctor whether the seizures are a side effect of the medication or if a change in medication is necessary.

Reply Date: 2023/09/03

More Info


Managing epilepsy, especially when it is a result of a head injury, can be a complex and challenging process. It is crucial to understand that while medications can effectively control seizures, they can also come with a range of side effects that may impact emotional health and overall quality of life.

In your case, it seems that you have experienced a resurgence of seizures 20 years after your initial head injury, which is not uncommon. Post-traumatic epilepsy can develop years after the injury, and managing it often requires a careful balance of medication to control seizures while minimizing side effects. The medication you mentioned, "帝拔癲" (likely referring to a brand name for a common anti-epileptic drug), may be contributing to your emotional distress, including feelings of depression and suicidal thoughts.

It is important to recognize that these emotional side effects can be a significant concern. Many anti-epileptic drugs (AEDs) have been associated with mood changes, including depression and anxiety. The mechanism behind this can vary; some medications may directly affect neurotransmitter levels in the brain, while others may indirectly influence mood through their sedative effects or by causing cognitive side effects that lead to frustration and emotional distress.

Given your experience of feeling low and having intrusive thoughts while on this medication, it is essential to address these symptoms with your healthcare provider. Here are some steps you might consider:
1. Communicate with Your Doctor: It is vital to have an open and honest conversation with your neurologist or prescribing physician about the side effects you are experiencing. They can assess whether the benefits of the medication outweigh the negative emotional impacts you are facing.

2. Medication Adjustment: Your doctor may suggest adjusting the dosage, switching to a different anti-epileptic medication, or even adding an antidepressant to help manage the emotional side effects. There are several AEDs available, and some may have a more favorable side effect profile for you.

3. Mental Health Support: In addition to medication management, consider seeking support from a mental health professional. Therapy can provide you with coping strategies to deal with the emotional challenges you are facing. Cognitive-behavioral therapy (CBT) is particularly effective for managing anxiety and depression.

4. Lifestyle Modifications: Incorporating lifestyle changes such as regular exercise, a balanced diet, and good sleep hygiene can also help improve your mood and overall well-being. Stress management techniques, such as mindfulness or yoga, can be beneficial as well.

5. Monitoring and Follow-Up: Regular follow-up appointments are crucial to monitor your seizure activity and any side effects from medications. Keeping a seizure diary can help you and your doctor identify patterns and triggers, which can inform treatment decisions.

6. Emergency Plan: If you ever experience thoughts of self-harm or suicide, it is crucial to seek immediate help. Contact a mental health professional, call a crisis hotline, or go to the nearest emergency room.

In conclusion, while managing epilepsy can be challenging, especially with the added complexity of emotional health, it is essential to work closely with your healthcare team. They can help tailor a treatment plan that addresses both your seizure control and emotional well-being. Remember, you are not alone in this journey, and there are resources and support available to help you navigate these challenges.

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