Should My Son Continue Taking Fish Oil with His Condition? - Internal Medicine

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In this situation, is it safe to continue taking fish oil?


Hello Dr.
Gao, my son is 21 years old and has been diagnosed with ankylosing spondylitis for nearly 4 years.
Initially, he was only taking Celebrex (he tried Voltaren but it was ineffective).
Over the past year, he has added Salazopyrin, taking 2 pills daily.
Although his pain is well controlled and his CRP levels have improved significantly (from around 1.6 to about 0.6), he has been unable to manage his ESR effectively (which often remains around 50, not occasionally, but frequently).
Recently, during the summer break, in addition to Salazopyrin and Celebrex, he started taking fish oil (3 capsules daily, with a total Omega-3 content of 1200 mg) and probiotics.
After one month, his hsCRP surprisingly dropped to 0.38, and his ESR decreased to 13, while his platelet count (PLT) was 225 (I mention PLT because it relates to the main concern later).
I believe this is a very good result, possibly coincidental, but it is great news for us.
Therefore, I plan to have my son continue taking Salazopyrin (I will stop Celebrex since he is no longer in pain) along with fish oil and probiotics for further observation.
However, not everything is perfect; I read online that fish oil may inhibit coagulation and lead to internal bleeding.
Since starting Salazopyrin, his platelet count has decreased from the previous range of 250-290 to 210-250 (it fluctuates between 210 and 250).
I would like to ask Dr.
Gao: 1) After taking fish oil for one month, with a PLT of 225 (previously fluctuating between 210-250 without fish oil), should I be concerned that continuing fish oil could lead to internal bleeding for my son? 2) Would you recommend that my son continue taking fish oil for observation? Thank you, doctor.

Shao, 50~59 year old female. Ask Date: 2023/09/11

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your question.
Here are my responses: 1) After taking fish oil for one month, my son's platelet count (PLT) is 225 (previously fluctuating between 210 and 250 without fish oil).
Should I be concerned that continuing fish oil could lead to internal bleeding? --> The difference in platelet count is minimal, and I believe it is unrelated to fish oil.
Additionally, I think the risk of internal bleeding is very low, so I suggest there is no need for concern.
2) Would Dr.
Gao recommend that my son continue taking fish oil for observation? --> I think that is a reasonable approach.
The Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare, is here to support you.

Reply Date: 2023/09/11

More Info


When considering whether your son should continue taking fish oil in the context of his ankylosing spondylitis (AS) and the associated laboratory results, it's important to weigh the benefits against potential risks. Fish oil, particularly its omega-3 fatty acids (EPA and DHA), has been shown to have anti-inflammatory properties, which can be beneficial for individuals with inflammatory conditions like AS. The reduction in hsCRP (high-sensitivity C-reactive protein) and ESR (erythrocyte sedimentation rate) that you've observed after introducing fish oil is promising and suggests that it may be contributing positively to his inflammatory status.

1. Concerns About Bleeding: You mentioned concerns about fish oil's potential to inhibit blood clotting and lead to internal bleeding. While it is true that high doses of fish oil can have anticoagulant effects, the risk of significant bleeding is generally low for most individuals, especially if they are not on other anticoagulant medications. The platelet count (PLT) of 225 is within the normal range (150-450 x 10^9/L), which indicates that your son's blood clotting ability is likely adequate. However, if he has any underlying bleeding disorders or is on other medications that affect coagulation, it would be prudent to consult with his healthcare provider.

2. Continuing Fish Oil: Given the positive impact on inflammatory markers and the absence of significant adverse effects so far, it seems reasonable to continue fish oil supplementation. The typical dosage of omega-3 fatty acids for anti-inflammatory effects is often around 1,000 to 3,000 mg per day, depending on individual needs and tolerability. Since your son is currently taking 1,200 mg daily, this falls within a commonly recommended range. However, it is essential to monitor his overall health and any potential side effects.

In addition to fish oil, maintaining a balanced diet rich in anti-inflammatory foods can further support his condition. Foods high in omega-3 fatty acids (like fatty fish, flaxseeds, and walnuts), fruits, vegetables, whole grains, and lean proteins can help manage inflammation. Staying hydrated and engaging in regular physical activity tailored to his capabilities can also contribute to overall well-being and potentially improve his symptoms.

Lastly, regular follow-ups with his healthcare provider are crucial. They can monitor his inflammatory markers, platelet count, and overall health status, adjusting his treatment plan as necessary. If any new symptoms arise or if there are significant changes in his lab results, it would be important to reassess the use of fish oil and any other supplements.

In conclusion, based on the current information, it appears beneficial for your son to continue taking fish oil while being mindful of his overall health and any potential interactions with other medications. Regular monitoring and communication with his healthcare provider will ensure that he receives the best possible care for his ankylosing spondylitis.

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