Diarrhea Side Effects of Ezetimibe: Duration and Recovery - Cardiology

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Ezetimibe, marketed under the brand name Zetia, is a medication primarily used to lower cholesterol levels in patients with hyperlipidemia. While it is generally well-tolerated, like any medication, it can have side effects, including gastrointestinal issues such as diarrhea. In your father's case, it seems that he has been experiencing significant diarrhea after starting Ezetimibe, and it's important to understand the potential relationship between the medication and his symptoms.

1. Onset of Diarrhea from Ezetimibe: Diarrhea as a side effect of Ezetimibe can occur, although it is not the most common side effect. The onset of diarrhea can vary from patient to patient. Some individuals may experience gastrointestinal side effects shortly after starting the medication, while others may not notice these effects until they have been on the medication for a longer period. In your father's case, it seems that the diarrhea became more pronounced after several weeks of treatment, which is consistent with the delayed onset that can occur with some patients.

2. Duration of Diarrhea After Stopping Ezetimibe: If Ezetimibe is discontinued, the duration of diarrhea can vary. Generally, once the medication is stopped, any gastrointestinal side effects, including diarrhea, should begin to resolve within a few days to a week. However, this can depend on individual factors such as the patient's overall health, the presence of any underlying gastrointestinal conditions, and how long the medication was taken. In your father's case, if he stops taking Ezetimibe, it would be reasonable to expect that his diarrhea may improve within a week, but close monitoring is essential.

3. Impact on Liver Function: The increase in liver enzymes (ALT/GPT) and creatinine levels you mentioned could potentially be related to Ezetimibe, although this is less common. Ezetimibe is primarily metabolized in the liver, and while it is generally considered safe, any medication can have effects on liver function, especially in older adults or those with pre-existing conditions. The slight elevation in liver enzymes and creatinine levels should be evaluated by a healthcare provider. It is crucial to discuss these lab results with your father's physician, who may recommend further testing or monitoring to ensure that there are no significant underlying issues.

In summary, while Ezetimibe can cause diarrhea, the onset and duration can vary among individuals. If your father is experiencing persistent diarrhea, it may be prudent to consult his healthcare provider about discontinuing the medication and exploring alternative cholesterol-lowering strategies. Additionally, the changes in liver function tests warrant further investigation to rule out any serious complications. Always ensure that any medication changes are done under the guidance of a healthcare professional.