Male Pattern Baldness: Medication Effects and Alternatives - Dermatology

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Inquiry about male pattern baldness and medications?


Hello, in recent years, I have been experiencing hair loss and visited the hospital.
After a blood test, the doctor found that I have iron and zinc deficiencies (ferritin 28, zinc 680), but also noted that my hair loss appears to be genetically linked to androgenetic alopecia.
Consequently, I was prescribed the diuretic Spironolactone.
I took the medication for a total of seven months, during which my menstrual cycle occurred twice a month.
Upon learning this, the doctor concluded that this medication was not suitable for me.
Initially, I thought this was just a normal side effect of the medication (irregular periods), but the doctor mentioned that other patients taking this medication do not experience having two menstrual cycles in a month like I do.
Is this side effect truly abnormal? The doctor immediately discontinued the medication and advised me to purchase a topical minoxidil solution instead.
I would like to ask, if androgenetic alopecia continues to be driven by hormones in the body without medication, is using only a topical solution effective?

QQ, 20~29 year old female. Ask Date: 2023/10/25

Dr. Wu Yuxin reply Dermatology


If male pattern baldness is confirmed, a combination of oral medication and topical hair growth solutions will yield the best results.

Reply Date: 2023/10/25

More Info


Male pattern baldness, also known as androgenetic alopecia, is a common condition that affects many men as they age. It is primarily driven by genetic factors and the influence of hormones, particularly dihydrotestosterone (DHT), which is a derivative of testosterone. DHT is known to shrink hair follicles, leading to thinner hair and eventual hair loss.
In your case, it seems that you have been prescribed spironolactone, a medication that is often used as a diuretic but also has anti-androgenic properties. This means it can help reduce the effects of androgens like DHT, which may be beneficial in treating hair loss. However, as you experienced, spironolactone can have side effects, particularly in women, such as menstrual irregularities. The fact that you experienced your menstrual cycle twice a month is not typical and suggests that this medication may not be suitable for you. It’s important to communicate any side effects to your healthcare provider, as they can help determine the best course of action.

When it comes to treating male pattern baldness, there are several options available. The most common medications include finasteride and minoxidil. Finasteride works by inhibiting the enzyme that converts testosterone to DHT, thereby reducing DHT levels in the scalp and potentially slowing hair loss. Minoxidil, on the other hand, is a topical solution that promotes hair growth by increasing blood flow to hair follicles.
You mentioned that your doctor suggested using a topical hair growth solution, which is a common alternative for those who may not tolerate oral medications well. Topical treatments like minoxidil can be effective in promoting hair regrowth and are often recommended for individuals who prefer not to take systemic medications. While it is true that without treatment, DHT will continue to affect hair follicles, using a topical solution can help mitigate some of these effects.
It’s also worth noting that hair loss treatments can take time to show results. Typically, it may take several months of consistent use before any noticeable improvement is seen. Additionally, the effectiveness of these treatments can vary from person to person, depending on factors such as the extent of hair loss and individual response to the medication.

In terms of alternatives to medication, some individuals explore natural remedies or lifestyle changes that may support hair health. This can include a balanced diet rich in vitamins and minerals, particularly those known to support hair growth, such as iron, zinc, and biotin. Stress management techniques and avoiding harsh hair treatments can also be beneficial.

In conclusion, while spironolactone may not have been the right choice for you due to its side effects, there are other effective treatments available for male pattern baldness. Topical solutions like minoxidil can be a viable option, and it’s important to have an open dialogue with your healthcare provider about your treatment preferences and any concerns you may have. Remember that hair loss is a common issue, and there are various paths to explore in managing it effectively.

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Dr. Jiang Zheen reply Dermatology
1. Regardless, this is my suggestion. 2. Treat it; you can take oral finasteride or apply minoxidil topical solution. Wishing you well.

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Please give it a try.

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