Interactions of Emergency Contraceptives and Antibiotics - Obstetrics and Gynecology

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Interactions of Emergency Contraceptive Pills


I have already taken the fifth pack from June 30 to July 20, the first pack from July 28 to August 17, the second pack from August 25 to September 14, the third pack from September 22 to October 12, and the fourth pack starting October 20.
However, from the evening of October 11 to October 14, I took antibiotics due to joint inflammation.
The medications are as follows: "Swiss" Dexamethasone capsules and "Johnson" Erythromycin tablets (5 mg) and Alendronate tablets (180 mg).
I would like to ask two questions: 1.
Since I had unprotected intercourse on October 20, but took antibiotics from October 11 to October 14, could this lead to pregnancy? 2.
On the day I take the first pill of the sixth pack, if I have unprotected intercourse before taking the pill and then take the first pill after the intercourse, is there a chance of pregnancy?

22, 20~29 year old female. Ask Date: 2023/10/27

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, antibiotics do not affect the effectiveness of birth control pills, so if you are taking contraceptives, you should not become pregnant.
Wishing you good health.

Reply Date: 2023/10/27

More Info


When discussing the interactions between emergency contraceptives and antibiotics, it is essential to understand how these medications work and their potential effects on each other. Emergency contraceptives, such as the "愛己" (Levonorgestrel), are designed to prevent pregnancy after unprotected intercourse. They work primarily by delaying ovulation, preventing fertilization, or inhibiting implantation of a fertilized egg. On the other hand, antibiotics are used to treat bacterial infections and can have various mechanisms of action depending on the specific antibiotic.

1. Impact of Antibiotics on Emergency Contraceptives:
The concern that antibiotics may reduce the effectiveness of emergency contraceptives stems from the interaction between certain antibiotics and hormonal contraceptives. However, most antibiotics do not significantly affect the efficacy of emergency contraceptive pills. The primary antibiotic of concern is rifampicin, which is known to induce liver enzymes that can lower the effectiveness of hormonal contraceptives. The antibiotics you mentioned, such as "得喜寧" (likely a reference to a type of penicillin) and "抑克敏" (likely a type of cephalosporin), do not have this effect. Therefore, taking these antibiotics from October 11 to October 14 should not impact the effectiveness of the emergency contraceptive taken on October 20.

2. Timing of Emergency Contraceptive Use:
Regarding your second question about the timing of taking the emergency contraceptive after unprotected intercourse, it is crucial to take the emergency contraceptive as soon as possible after the unprotected event. The effectiveness of emergency contraceptives decreases the longer you wait. If you had unprotected intercourse on October 20 and took the emergency contraceptive afterward, there is a possibility of pregnancy, especially if ovulation has already occurred. The emergency contraceptive is most effective when taken within 72 hours after unprotected intercourse, but it can still be taken up to 5 days after, with decreasing effectiveness.

In summary, based on the information provided:
- The antibiotics you took (得喜寧 and 抑克敏) should not interfere with the effectiveness of the emergency contraceptive taken on October 20.

- If you had unprotected intercourse on October 20 and took the emergency contraceptive afterward, there is a risk of pregnancy, particularly if ovulation occurred before taking the pill.

Additional Considerations:
- It is always advisable to consult with a healthcare provider regarding the use of antibiotics and emergency contraceptives, especially if you have concerns about potential interactions or effectiveness.

- If you experience any unusual symptoms or have concerns about potential pregnancy, consider taking a pregnancy test or consulting your healthcare provider for further guidance.

- Maintaining open communication with your healthcare provider about all medications you are taking, including antibiotics and contraceptives, can help ensure safe and effective treatment.

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