Leg Swelling: When to Seek Specialized Medical Help - Cardiology

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Bilateral leg edema?


My husband has been on antiviral medication for hepatitis B for 2 years.
He has been experiencing swelling in both legs for the past 4 months, particularly in the calves, ankle joints, and feet, which is painful.
Initially, we thought it was due to poor circulation from prolonged sitting.
However, the swelling became red, hot, and unbearable, leading us to visit the emergency room.
The preliminary diagnosis was gout complicated by cellulitis.
He was hospitalized for 7 days and has been discharged for over a month now.
He has seen specialists in nephrology, cardiology (echocardiogram), infectious diseases, pulmonology, and gastroenterology, and all tests have shown no issues.
His uric acid levels are normal, and there are no gout crystals.
However, he still experiences swelling and pain.
The rheumatology and immunology department suggested we seek further consultation.
Which specialty should we refer him to? Thank you!

+An, 40~49 year old female. Ask Date: 2023/11/07

Dr. Wu Xueming reply Cardiology


If the heart examination is normal, it indicates that heart failure is not the cause.
It is recommended to avoid excessive salt intake and to increase physical activity to improve blood circulation, in order to see if the symptoms of edema can be alleviated.

Reply Date: 2023/11/07

More Info


When it comes to leg swelling, especially in the context of a patient with a history of hepatitis B and prolonged use of antiviral medication, it is crucial to approach the situation with a comprehensive understanding of potential underlying causes. The symptoms you've described—bilateral leg swelling, pain, and redness—can arise from various medical conditions, and it’s essential to consider each possibility carefully.

Given that your husband has already undergone evaluations by several specialists, including nephrology, cardiology, infectious disease, and gastroenterology, and that these consultations did not reveal any significant issues, it may be time to consider other potential causes of his symptoms. The fact that he has been diagnosed with gout and cellulitis (a bacterial skin infection) suggests that inflammation is a significant factor in his condition. However, since his uric acid levels are normal and he does not have gout crystals, it may be necessary to explore other avenues.

One important consideration is the possibility of chronic venous insufficiency (CVI), a condition where the veins in the legs struggle to send blood back to the heart, leading to swelling and discomfort. This condition can be exacerbated by prolonged sitting or standing, and it can also be influenced by factors such as obesity, pregnancy, or a history of blood clots. A vascular specialist, or a doctor specializing in vein health, could provide valuable insights into whether CVI is contributing to your husband's symptoms.

Another potential area of concern is the possibility of lymphedema, which is a condition characterized by swelling due to the accumulation of lymph fluid. This can occur after infections, surgeries, or radiation therapy, and it may require specialized treatment from a lymphedema therapist or a specialist in lymphatic disorders.

Additionally, autoimmune conditions can also lead to swelling and pain in the legs. Since your husband has already been referred to a rheumatologist, this is a good step. The rheumatologist can evaluate for conditions such as rheumatoid arthritis, lupus, or other inflammatory disorders that may not have been previously considered.

In summary, given the complexity of your husband's symptoms and the fact that multiple specialists have not identified a clear cause, I would recommend the following steps:
1. Consult a Vascular Specialist: To evaluate for chronic venous insufficiency or other vascular issues that could be causing the swelling and pain.

2. Follow Up with a Rheumatologist: If not already done, ensure that the rheumatologist conducts a thorough evaluation for autoimmune diseases that could be contributing to his symptoms.

3. Consider a Lymphedema Specialist: If there is suspicion of lymphedema, a specialist in this area can provide targeted treatment options.

4. Monitor Symptoms: Keep a detailed record of symptoms, including any changes in swelling, pain levels, and any new symptoms that may arise. This information can be invaluable for healthcare providers in diagnosing the issue.

5. Lifestyle Modifications: Encourage your husband to engage in gentle physical activity, elevate his legs when sitting, and consider compression stockings if advised by a healthcare provider, as these can help manage swelling.

It’s essential to remain proactive in seeking care and advocating for your husband’s health. If symptoms worsen or new symptoms develop, do not hesitate to seek immediate medical attention.

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