Pathology Reports for Minimally Invasive Lung Adenocarcinoma - Pulmonology

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Questions regarding the pathology report of lung adenocarcinoma?


Hello Doctor: After undergoing low-dose lung cancer screening, I was diagnosed with lung adenocarcinoma.
At the beginning of the month, I had a thoracoscopic resection of the tumor, and the doctor informed me that it was in situ cancer.
However, I saw in the pathology report that it is minimally invasive adenocarcinoma.
From my online research, I found that minimally invasive adenocarcinoma is classified as stage I cancer, which has left me confused.
I would like to seek a second opinion from another doctor.
Below is the pathology report; I would appreciate your clarification.
Thank you.
Pathological Diagnosis: Lung, right middle lobe, wedge resection - S/P frozen section, minimally invasive adenocarcinoma.
Margin is free of tumor.
pTmiN0.
Gross Description:
1.
Specimen received: Lung, size: 9x4x2.5 cm
2.
Tumor Site: Periphery
3.
Gross Tumor Size: invasive solitary: 0.3x0.3x0.3 cm
4.
Gross tumor patterns: Well defined
5.
Additional description: Nil
Sections taken and labeled as: A-2) tumor, B1-2) nontumor in wedge resection, Fx1-3) frozen control.
Microscopic Description:
1.
Histologic type: Minimally invasive adenocarcinoma, nonmucinous
2.
Histologic Grade (according to the main histologic type): G1: Well differentiated
3.
Tumor size: Total Tumor Size: Greatest dimension (centimeters): 0.3 cm + Additional dimensions (centimeters): 0.3x0.3 cm
4.
Tumor Focality: Single tumor
5.
Lymphovascular invasion: Not identified
6.
Perineural invasion: Not identified
7.
Spread Through Air Spaces (STAS): Not identified
8.
Visceral Pleura invasion: Not identified (PL0)
9.
Direct invasion of Adjacent Structures: No adjacent structures present
10.
Margin (Bronchial and/or vascular and/or parenchymal margin): Uninvolved by carcinoma
11.
Treatment Effect: No known presurgical therapy
12.
Lymph nodes: The lymph nodes are all without metastatic tumor
13.
Pathologic Stage Classification (pTNM, AJCC 8th Edition):
- Primary Tumor (pT): pT1mi: Minimally invasive adenocarcinoma: adenocarcinoma (?3 cm in greatest dimension) with a predominantly lepidic pattern and ?5 mm invasion in greatest dimension (See note C)
- Regional Lymph Nodes (pN): pNX: Regional lymph nodes cannot be assessed
- Distant Metastasis (pM): pMx: unknown Distant metastasis
14.
Additional Pathologic Findings: Anthracosis
15.
Ancillary Studies: [immunohistochemical stains] CK7: positive staining in tumor cells.
TTF-1: positive staining in tumor cells.
Napsin A: positive staining in tumor cells.
Synaptophysin: negative staining in tumor cells.
p40: negative staining in tumor cells.

Chen Ling, 50~59 year old female. Ask Date: 2023/11/20

Dr. Huang Yiwen reply Pulmonology


Dear Chen Ling: In terms of tumor size, it is classified as carcinoma in situ.
It has been excised, and follow-up is sufficient.
There is no need for excessive worry.
Changhua Hospital cares about you.

Reply Date: 2023/11/20

More Info


Understanding pathology reports, especially in the context of lung adenocarcinoma, can be quite complex and often leads to confusion for patients. In your case, the pathology report indicates that you have a "minimally invasive adenocarcinoma," which is indeed a subtype of lung cancer characterized by limited invasion into surrounding tissues. This is a critical distinction because it has implications for staging and treatment.


Key Points from Your Pathology Report:
1. Diagnosis: The report confirms a diagnosis of minimally invasive adenocarcinoma, which is a form of lung cancer that is typically associated with a better prognosis compared to more invasive forms. The term "minimally invasive" suggests that the tumor has not penetrated deeply into the lung tissue, which is a favorable characteristic.

2. Tumor Size and Margins: The tumor size is reported as 0.3 cm, which is quite small. Importantly, the margins are free of tumor, meaning that the cancer has not spread to the surrounding lung tissue. This is a positive finding as it indicates that the surgical removal was likely complete.

3. Pathologic Stage: The report indicates a pathologic stage of pTmiN0, which means that there is minimal invasion (mi) and no regional lymph node involvement (N0). This aligns with your understanding that minimally invasive adenocarcinoma is often classified as stage I, which is typically associated with a better prognosis and lower risk of recurrence.

4. Histological Features: The tumor is well-differentiated (G1), indicating that the cancer cells resemble normal cells and are less aggressive. The absence of lymphovascular invasion and perineural invasion further supports a less aggressive disease course.

5. Immunohistochemical Staining: The positive staining for markers such as CK7, TTF-1, and Napsin A confirms the adenocarcinoma diagnosis, as these markers are commonly associated with lung adenocarcinomas.


Addressing Your Concerns:
- Confusion Between Terms: The term "original cancer" versus "minimally invasive adenocarcinoma" can be confusing. While your doctor may have referred to it as "original cancer," the pathology report provides a more specific classification that indicates a less aggressive form of lung cancer.
- Need for Further Treatment: Given the pTmiN0 classification, the current standard of care often involves careful monitoring rather than immediate additional treatment, especially if the tumor has been completely resected. However, your oncologist may recommend follow-up imaging or surveillance to ensure that there is no recurrence.

- Prognosis: The prognosis for minimally invasive adenocarcinoma is generally favorable, particularly when detected early and treated appropriately. Regular follow-ups and imaging studies are essential to monitor for any signs of recurrence.


Recommendations:
1. Follow-Up: It is crucial to maintain regular follow-up appointments with your oncologist. They will likely recommend periodic imaging studies to monitor for any changes.

2. Discuss Concerns: If you have lingering concerns about the terminology or the implications of your diagnosis, do not hesitate to discuss these with your healthcare provider. They can provide clarity and reassurance.

3. Stay Informed: Educating yourself about lung cancer and its various subtypes can empower you to engage in informed discussions with your healthcare team.

In summary, your pathology report indicates a favorable diagnosis of minimally invasive adenocarcinoma with no evidence of lymph node involvement. This suggests a good prognosis, and while monitoring is essential, aggressive treatment may not be necessary at this stage. Always consult with your healthcare provider for personalized advice and treatment options.

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