Managing Toenail Fungus: Safe Medication Options and Liver Health - Dermatology

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Medications for nail fungus?


Hello Doctor, I have been troubled by a toenail fungus issue affecting all ten of my toes for the past few years.
Last year, I visited a dermatologist from June 11, 2022, to September 1, 2022, and was prescribed 100 mg of Itraconazole capsules.
I took it for three months, and there was some improvement, but in the past few months, it has worsened again.
I then went to another clinic, and this time I also mentioned that I have a patch on my scalp near my neck that is very itchy, slightly peeling, and red.
They diagnosed it as a fungal infection and prescribed 250 mg of Griseofulvin tablets on November 11, 2023.
I am concerned because my recent health check showed an SGPT level of 60.8.
I would like to know if it is safe for me to take this medication.
I read online that Griseofulvin can be harmful to the liver, so I am hesitant to take it.
The doctor also suggested that I self-pay for "Astar" Sican Capsules 150 mg.
I would like to know if taking this along with Griseofulvin would be less harmful to my liver.
Additionally, my health check report (which included a gastroscopy) showed an eGFR of 80.2 and a BUN of 6.5, both of which are slightly below normal, so I am also worried about whether this medication could be harmful to my kidneys.
I apologize for asking so many questions, but I am really distressed.

S, 30~39 year old female. Ask Date: 2023/11/21

Dr. Wu Yuxin reply Dermatology


If you feel that taking medication is a burden, you need to carefully consider it.
After all, the decision to take medication or not is ultimately yours; the doctor cannot make the final decision for you, and you must weigh your options.

Reply Date: 2023/11/21

More Info


Managing toenail fungus, particularly in the context of existing liver health concerns, requires careful consideration of medication options and potential side effects. Toenail fungus, or onychomycosis, can be a persistent and frustrating condition, often requiring systemic antifungal treatment for effective resolution. However, as you noted, the use of certain antifungal medications can pose risks, especially for individuals with liver health issues.

In your case, you have been prescribed two different antifungal medications: 易克黴膠囊 (likely a formulation containing terbinafine) and 灰黴素錠 (griseofulvin). Both of these medications can be effective against fungal infections, but they also have potential side effects, particularly concerning liver function. Griseofulvin, in particular, has been associated with liver toxicity, and it is essential to monitor liver enzymes during treatment. Your SGPT level of 60.8 indicates a mild elevation, which could suggest some degree of liver stress or damage.
Given your history of toenail fungus and the recent diagnosis of a fungal infection on your scalp, it is understandable that you are seeking effective treatment while being cautious about your liver health. The recommendation of 安星 (Sican Capsules) as a supportive treatment is interesting, as it is often marketed as a liver-protective supplement. However, it is crucial to note that while such supplements may help support liver health, they should not be considered a substitute for medical treatment or a way to mitigate the side effects of antifungal medications.

When considering the concurrent use of griseofulvin and Sican Capsules, it is essential to consult with your healthcare provider. They can assess the potential interactions and the overall safety of using these medications together. It is also vital to continue monitoring your liver function through regular blood tests, especially if you are taking medications that could impact liver health.

In addition to medication, there are several lifestyle modifications that can help manage toenail fungus and support overall health:
1. Maintain Good Hygiene: Keep your feet clean and dry, as fungi thrive in moist environments. Make sure to dry your feet thoroughly after bathing, especially between the toes.

2. Wear Breathable Footwear: Choose shoes made of breathable materials to reduce moisture buildup. Avoid tight-fitting shoes that can create a warm, damp environment conducive to fungal growth.

3. Use Antifungal Powders or Sprays: Consider using antifungal powders or sprays on your feet and in your shoes to help prevent fungal infections.

4. Regular Nail Care: Keep your toenails trimmed and filed to reduce the area where fungi can grow. If you have thickened nails, consider seeing a podiatrist for professional nail care.

5. Diet and Hydration: Maintain a balanced diet rich in vitamins and minerals to support your immune system. Staying well-hydrated can also help your liver function optimally.

6. Avoid Sharing Personal Items: Do not share towels, shoes, or nail clippers with others to reduce the risk of spreading or contracting fungal infections.

In conclusion, while managing toenail fungus, it is crucial to balance effective treatment with the need to protect your liver health. Always consult with your healthcare provider before making any changes to your medication regimen or adding supplements. Regular monitoring of liver function tests will help ensure that your treatment plan remains safe and effective. If you experience any new or worsening symptoms, such as increased fatigue, jaundice, or abdominal pain, seek medical attention promptly. Your health and well-being are paramount, and a collaborative approach with your healthcare team will help you navigate this challenging situation.

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