Treatment for Athlete's Foot and Nail Fungus - Pharmacology

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Medications for athlete's foot?


I went to see a doctor because my feet have been peeling, and there is no pain or itching.
The doctor diagnosed me with athlete's foot and onychomycosis (fungal nail infection).
The doctor prescribed Sporanox (itraconazole) for me.
Is it harmful to the liver? There is also a topical medication that I find strange; it’s called "Solucon," and it only states that its function is to exfoliate, not to combat fungi.
Will this be effective? I know it contains salicylic acid.
The doctor also instructed me to return for a follow-up appointment once a week.
Is that necessary? Thank you for your response.

Xiao Yu, 20~29 year old female. Ask Date: 2005/04/24

Dr. Wu Huiling reply Pharmacology


Hello! "Athlete's foot" is a superficial fungal infection that occurs on the feet, often leading to thickening of the plantar keratin (which can be treated with exfoliants like salicylic acid) and even fissures.
It is commonly associated with nail involvement, resulting in onychomycosis.
After taking the new generation oral antifungal medication Sporanox, it is important to monitor liver function monthly due to the drug's hepatic metabolism; if liver function is significantly affected, the medication should be discontinued.
The incidence of hepatic and biliary dysfunction is approximately 1 in 160,000 (source: report from the Department of Health, Executive Yuan, Republic of China).
The medication is taken once daily, with treatment duration of six weeks for fingernail infections and twelve weeks for toenail infections (note: it must be taken continuously without interruption).
The treatment success rate can exceed 80%.
In the initial treatment phase, physicians usually recommend a follow-up appointment after one week to ensure patient adherence to the medication regimen and to assess medication safety.

Reply Date: 2005/04/24

More Info


When dealing with conditions like athlete's foot (tinea pedis) and nail fungus (onychomycosis), it's essential to understand both the nature of these infections and the treatment options available. Your concerns about the medications prescribed, particularly Sporanox (itraconazole), and the topical treatment, are valid and warrant a thorough discussion.


Understanding Athlete's Foot and Nail Fungus
Athlete's foot is a fungal infection that typically affects the skin on the feet, leading to symptoms such as peeling, redness, and sometimes itching. Nail fungus, on the other hand, can cause discoloration, thickening, and separation of the nail from the nail bed. Both conditions are often caused by dermatophytes, a type of fungus that thrives in warm, moist environments.


Treatment Options
1. Oral Antifungal Medications: Sporanox (itraconazole) is an oral antifungal medication that is effective against various fungal infections, including those affecting the skin and nails. While it can be effective, it is important to monitor liver function, as itraconazole can affect the liver. Regular blood tests to check liver enzymes may be necessary, especially if you have a history of liver issues or are taking other medications that could impact liver health.

2. Topical Treatments: The topical medication you mentioned, "速立康" (likely a brand name for a product containing salicylic acid), is primarily used for its keratolytic properties, meaning it helps to exfoliate and remove dead skin. While salicylic acid can be beneficial for treating conditions like warts or psoriasis, it is not an antifungal agent. Therefore, while it may help with the peeling skin associated with athlete's foot, it may not directly combat the fungal infection itself. It’s crucial to use a topical antifungal cream or solution in conjunction with any keratolytic treatment to effectively address the fungal infection.

3. Follow-Up Appointments: Your doctor’s recommendation for weekly follow-ups is not uncommon, especially in cases of fungal infections. Regular check-ups allow the physician to monitor your progress, adjust treatment if necessary, and ensure that the infection is responding to the medications. It’s important to adhere to this schedule, as fungal infections can be stubborn and may require adjustments in treatment.


Additional Considerations
- Hygiene Practices: Maintaining good foot hygiene is crucial in managing and preventing fungal infections. This includes keeping your feet dry, especially between the toes, and wearing breathable footwear. If you sweat excessively, consider using antifungal powders or sprays to keep your feet dry.

- Avoiding Recurrence: To prevent recurrence of athlete's foot and nail fungus, it’s important to avoid walking barefoot in communal areas, such as locker rooms or swimming pools, and to ensure that your shoes and socks are clean and dry. If you have a history of these infections, consider using antifungal treatments as a preventive measure during warmer months or when you know you’ll be in moist environments.

- Diet and Lifestyle: A healthy diet that supports your immune system can also play a role in fighting off fungal infections. Staying hydrated, eating a balanced diet rich in vitamins and minerals, and managing stress can contribute to overall skin health.

In conclusion, while Sporanox is a potent antifungal medication, it’s essential to monitor liver function and follow your doctor's advice regarding follow-up appointments. The topical treatment should ideally be an antifungal agent rather than just a keratolytic. By maintaining good hygiene practices and following your treatment plan, you can effectively manage and potentially eliminate these fungal infections. If you have further concerns about your treatment or any side effects, don’t hesitate to discuss them with your healthcare provider.

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