Interactions Between Blood Pressure Medications and Other Drugs - Cardiology

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Interactions between antihypertensive medications and other drugs?


I am currently taking Norvasc (Amlodipine) 5 mg for blood pressure management, but I also visited another specialist who prescribed the following two medications to be taken at bedtime: Fluzine (Fluoxetine) 5 mg and Diazepam 2 mg.
Norvasc is taken in the morning, and all of these medications are long-acting.
Can these medications be taken together? Are there any potential interactions? Thank you, doctor.

Jiaxue, 40~49 year old female. Ask Date: 2023/11/21

Dr. Li Shengkai reply Cardiology


Norvasc is a commonly used antihypertensive medication with a long half-life, so even if you forget to take it for a day, your blood pressure will likely remain normal.
The three medications you mentioned can be taken together without significant interactions, and if you prefer convenience, Norvasc can even be adjusted to be taken at night along with the others.

Reply Date: 2023/11/21

More Info


When considering the potential interactions between blood pressure medications like Norvasc (Amlodipine) and other drugs such as Fluzine (Fluoxetine) and Diazepam, it is essential to understand how these medications work and their effects on the body.

Norvasc is a calcium channel blocker commonly prescribed for hypertension and angina. It works by relaxing blood vessels, which helps to lower blood pressure and improve blood flow. Its long half-life means that it maintains stable blood pressure control even if a dose is missed occasionally.

Fluzine, which contains Fluoxetine, is a selective serotonin reuptake inhibitor (SSRI) used primarily to treat depression and anxiety disorders. Diazepam is a benzodiazepine that acts as a sedative and muscle relaxant, often prescribed for anxiety, muscle spasms, and seizures. Both Fluoxetine and Diazepam can have sedative effects, which may be compounded when taken together.

In general, there are no significant direct interactions reported between Norvasc and either Fluoxetine or Diazepam. However, caution is warranted due to the potential for increased sedation when combining Fluoxetine and Diazepam. This combination can lead to enhanced drowsiness, dizziness, or difficulty concentrating, particularly in older adults. Therefore, it is advisable to monitor how you feel when taking these medications together, especially if you are engaging in activities that require alertness, such as driving.

Moreover, while Norvasc does not have a direct interaction with either of the other medications, it is crucial to consider the overall health profile and any underlying conditions. For instance, if you have a history of heart issues or are taking other medications, the combination of these drugs should be evaluated by your healthcare provider.

Additionally, both Fluoxetine and Diazepam can influence blood pressure indirectly. Fluoxetine may lead to changes in blood pressure, particularly when initiating treatment or adjusting doses. Diazepam can cause hypotension, especially in higher doses or when combined with other medications that lower blood pressure. Therefore, it is essential to monitor your blood pressure regularly and report any significant changes to your healthcare provider.

In conclusion, while taking Norvasc, Fluoxetine, and Diazepam together does not present significant direct interactions, the potential for increased sedation and the indirect effects on blood pressure warrant careful monitoring. Always consult with your healthcare provider before making any changes to your medication regimen, and ensure that they are aware of all the medications you are taking, including over-the-counter drugs and supplements. Regular follow-ups will help to manage your blood pressure effectively while minimizing any risks associated with polypharmacy.

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