Can You Get Pregnant While Taking Medroxyprogesterone? - Obstetrics and Gynecology

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Can you get pregnant while taking Medroxyprogesterone?


Hello, I expect my period to start on November 23.
I went to the gynecologist to get medication to delay my period because I will be traveling.
The doctor prescribed Medroxyprogesterone for me to take from November 19 to November 23.
However, I had unprotected intercourse on November 21.
Is there a possibility of getting pregnant?

Haizi de ma, 30~39 year old female. Ask Date: 2023/11/22

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, the chances of pregnancy should be low.
Wishing you good health.

Reply Date: 2023/11/22

More Info


When considering the question of whether one can get pregnant while taking Medroxyprogesterone (often referred to as Medrone), it is essential to understand the medication's purpose and its effects on the menstrual cycle and fertility.

Medroxyprogesterone is a synthetic form of the hormone progesterone, which is commonly used to regulate menstrual cycles, treat abnormal uterine bleeding, and as part of hormone replacement therapy. It is also used to delay menstruation, as in your case, where you were prescribed the medication to postpone your period due to travel plans.

In your situation, you started taking Medroxyprogesterone on November 19 and had unprotected intercourse on November 21. The timing of your medication and the nature of your menstrual cycle are crucial factors in determining the likelihood of pregnancy.

1. Mechanism of Action: Medroxyprogesterone works by mimicking the effects of natural progesterone in the body. It helps to stabilize the endometrial lining and can prevent ovulation. If taken correctly, it can effectively delay menstruation and reduce the chances of ovulation occurring during the time you are taking the medication.

2. Timing of Ovulation: Ovulation typically occurs about 14 days before the start of your next menstrual period. If your cycle is regular and you were expected to start your period on November 23, ovulation would likely have occurred around November 9. By taking Medroxyprogesterone, you may have altered your hormonal environment, which could potentially delay ovulation. However, if ovulation had already occurred before you started the medication, there is still a possibility of pregnancy if unprotected intercourse happens shortly after ovulation.

3. Effectiveness of Medroxyprogesterone: While Medroxyprogesterone can help regulate the menstrual cycle and prevent ovulation, it is not 100% effective in preventing pregnancy, especially if taken for the purpose of delaying menstruation. The effectiveness can also vary based on individual hormonal responses and the timing of administration.

4. Pregnancy Testing: If you are concerned about the possibility of pregnancy, it is advisable to wait until after your expected period (in this case, after November 23) to take a home pregnancy test for the most accurate results. If your period does not arrive as expected, a pregnancy test can help clarify your situation.

5. Consulting a Healthcare Provider: If you have further concerns or if your menstrual cycle does not return to normal after stopping the medication, it is essential to consult with your healthcare provider. They can provide personalized advice based on your medical history and current situation.

In summary, while taking Medroxyprogesterone can reduce the likelihood of pregnancy by preventing ovulation, it is not foolproof. Given that you had unprotected intercourse during the time you were taking the medication, there is a possibility of pregnancy, especially if ovulation had already occurred. Monitoring your menstrual cycle and consulting with a healthcare provider will be crucial steps moving forward.

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